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Are environmental exposures to selenium, heavy metals, and pesticides risk factors for amyotrophic lateral sclerosis?

机译：硒，重金属和农药的环境暴露是否是肌萎缩性侧索硬化的危险因素？

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摘要

The etiology of sporadic amyotrophic lateral sclerosis (ALS), the most common form of this degenerative disease of the motor neurons, is still unknown, despite extensive investigation of several genetic and environmental potential risk factors. We have reviewed laboratory and epidemiological studies assessing the role of exposure to neurotoxic chemicals (metalloid selenium; heavy metals mercury, cadmium, and lead; pesticides) in ALS etiology by summarizing the results of these investigations and examining their strengths and limitations. Despite limitations in the exposure assessment methodologies typically used in human studies, we found suggestive epidemiological evidence and biologic plausibility for an association between ALS and antecedent overexposure to environmental selenium and pesticides. The relation with mercury, cadmium, and lead appears weaker.
机译：尽管对多种遗传和环境潜在危险因素进行了广泛研究，但散发性肌萎缩性侧索硬化症（ALS）的病因仍是未知的，这是运动神经元变性疾病的最常见形式。我们通过总结这些研究的结果并检查其优势和局限性，回顾了实验室和流行病学研究，评估了神经毒性化学物质（准金属硒，重金属汞，镉和铅；农药）在神经毒性化学物质中的作用。尽管在人类研究中通常使用的接触评估方法存在局限性，但我们发现提示性的流行病学证据和生物学上的合理性证明了ALS与先前对环境硒和农药的过度接触之间的关联。与汞，镉和铅的关系似乎较弱。

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  • 来源
    《Reviews on environmental health》 |2012年第1期|p.19-41|共23页
  • 作者

    Marco Vinceti; Ilaria Bottecchi; Anna Fan; Yoram Finkelstein; Jessica Mandrioli;

  • 作者单位

    CREAGEN - Dipartimento di Scienze di Sanita Pubblica, Universita di Modena e Reggio Emilia, Padiglione De Sanctis, Via Amendola 2,42122 Reggio Emilia, Italia;

    CREAGEN - Environmental, Genetic and Nutritional Epidemiology Research Center, Department of Public Health Sciences, University of Modena and Reggio Emilia, Reggio Emilia, Italy;

    Pesticide and Environmental Toxicology Branch, Office of Environmental Health Hazard Assessment, State of California, Oakland, CA, USA;

    Neurology and Toxicology Service and Unit, Shaare Zedek Medical Center, Jerusalem, Israel;

    Department of Neurosciences, University of Modena and Reggio Emilia and Local Health Unit of Modena, Modena, Italy;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    heavy metals; motor neuron disease; neurotoxins; pesticides.;

    机译：重金属;运动神经元疾病神经毒素;农药;

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