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首页> 外文期刊>Rheumatology International >Elevated plasma level of HMGB1 is associated with disease activity and combined alterations with IFN-alpha and TNF-alpha in systemic lupus erythematosus
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Elevated plasma level of HMGB1 is associated with disease activity and combined alterations with IFN-alpha and TNF-alpha in systemic lupus erythematosus

机译：HMGB1血浆水平升高与疾病活动性以及系统性红斑狼疮中IFN-α和TNF-α的联合改变有关

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摘要

Recent studies indicate that high-mobility group box protein 1 (HMGB1) contributes to the pathogenesis of diverse autoimmune disorders. It induces the production of interferon-alpha (IFN-alpha) and tumor necrosis factor alpha (TNF-alpha) in vitro. In the present study, plasma HMGB1, TNF-alpha, and IFN-alpha were determined with ELISA in 37 patients with systemic lupus erythematosus (SLE) and 39 age- and sex-matched healthy controls (HC). The possible associations of these cytokines with disease activities, autoantibodies, and certain laboratory parameters were also explored. The plasma levels of HMGB1, TNF-alpha, and IFN-alpha were increased in SLE patients compared with those of HC (P 0.05). Moreover, the levels of HMGB1 and TNF-alpha in the active SLE patients were elevated compared with those in inactive patients and HC. Additionally, plasma HMGB1 was positively correlated with peripheral neutrophils, and plasma TNF-alpha was positively correlated with anti-Sm, ESR and CRP, while plasma IFN-alpha was inversely correlated with the age and platelet level in SLE patients. Our data indicated that increased plasma HMGB1 was associated with disease activity in SLE, which was similar to TNF-alpha. High level of plasma IFN-alpha may be related to nephritis and thrombocytopenia in SLE.
机译：最近的研究表明，高迁移率的组框蛋白1（HMGB1）有助于多种自身免疫性疾病的发病机理。它在体外诱导产生干扰素-α（IFN-α）和肿瘤坏死因子α（TNF-α）。在本研究中，通过ELISA测定了37例系统性红斑狼疮（SLE）和39个年龄和性别匹配的健康对照（HC）患者的血浆HMGB1，TNF-α和IFN-α。还探讨了这些细胞因子与疾病活动，自身抗体和某些实验室参数之间的可能联系。与HC相比，SLE患者的HMGB1，TNF-α和IFN-α血浆水平升高（P <0.05）。此外，活跃的SLE患者的HMGB1和TNF-α水平高于非活跃的患者和HC。此外，血浆HMGB1与周围中性粒细胞呈正相关，血浆TNF-α与抗Sm，ESR和CRP呈正相关，而血浆IFN-α与SLE患者的年龄和血小板水平呈负相关。我们的数据表明血浆HMGB1升高与SLE中的疾病活动有关，这与TNF-α相似。 SLE中血浆IFN-α水平高可能与肾炎和血小板减少有关。

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  • 来源
    《Rheumatology International》 |2012年第2期|p.395-402|共8页
  • 作者

    Chun-yan Ma; Yu-lian Jiao; Jie Zhang; Qing-rui Yang; Zhi-fen Zhang; Ya-juan Shen; Zi-jiang Chen; Yue-ran Zhao;

  • 作者单位

    Department of Central Laboratory, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, People’s Republic of China;

    Department of Central Laboratory, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, People’s Republic of China;

    Department of Central Laboratory, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, People’s Republic of China;

    Department of Rheumatology, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, People’s Republic of China;

    Department of Laboratory Medicine, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, People’s Republic of China;

    Department of Laboratory Medicine, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, People’s Republic of China;

    Department o;

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  • 正文语种 eng
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  • 关键词

    Systemic lupus erythematosus; High-mobility group box protein 1; Interferon- alpha; Tumor necrosis factor-alpha;

    机译：系统性红斑狼疮;高迁移率族盒蛋白1;干扰素-α;肿瘤坏死因子-α;

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