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首页> 外文期刊>Rheumatology International >A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population
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A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population

机译：TNFSF4基因的单核苷酸多态性与中国汉族人群的系统性红斑狼疮有关

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摘要

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. Recently, single-nucleotide polymorphisms (SNPs) in tumor necrosis factor (TNF) superfamily gene TNFSF4 have been shown to be associated with SLE in European and Hong Kong Chinese populations. But it is unknown whether it is also associated with the disease in Mainland Chinese Han population. We genotyped the SNPs rs1234315 near the TNFSF4 gene in 1,344 SLE patients and 4,315 controls of Chinese Han population and confirmed the association between the SNP and the SLE [odds ratios (ORs) of 1.45 and P values of 1.5 × 10−16]. The stratification analyses showed that rs1234315 was more strongly associated with SLE patients with arthritis. Our study not only suggested that the TNFSF4 gene was associated with SLE in Chinese Han population, but also implied that it might be a common genetic factor predisposing to the development of SLE in multiple populations.
机译：系统性红斑狼疮（SLE）是具有复杂遗传遗传的原型自身免疫性疾病。最近，在欧洲和香港华人人群中，肿瘤坏死因子（TNF）超家族基因TNFSF4的单核苷酸多态性（SNPs）与SLE相关。但尚不清楚它是否也与中国大陆汉族人群的疾病有关。我们对1,344名SLE患者和4,315名中国汉族人群的TNFSF4基因附近的SNPs rs1234315进行了基因分型，并确认了SNP与SLE之间的相关性[比​​值比（OR）为1.45，P值为1.5×10 −16 ]。分层分析表明，rs1234315与SLE关节炎患者相关性更高。我们的研究不仅表明TNFSF4基因与中国汉族人群的SLE有关，而且暗示它可能是导致多族群SLE发展的常见遗传因素。

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