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An Interagency Comparison of Screening-Level Risk Assessment Approaches

机译：筛查级风险评估方法的机构间比较

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Approaches to risk assessment have been shown to vary among regulatory agencies and across jurisdictional boundaries according to the different assumptions and, justifications used. Approaches to screening-level risk assessment from six international agencies were applied to an urban case study focusing on benzo[a]pyrene (B[a]P) exposure and compared in order to provide insight into the differences between agency methods, assumptions, and justifications. Exposure estimates ranged four-fold, with most of the dose stemming from exposure to animal products (8-73%) and plant products (24-88%). Total cancer risk across agencies varied by two orders of magnitude, with exposure to air and plant and animal products contributing most to total cancer risk, while the air contribution showed the greatest variability (1-99%). Variability in cancer risk of 100-fold was attributed to choices of toxicological reference values (TRVs), either based on a combination of epidemiological and animal data, or on animal data. The contribution and importance of the urban exposure pathway for cancer risk varied according to the TRV and, ultimately, according to differences in risk assessment assumptions and guidance. While all agency risk assessment methods are predicated on science, the study results suggest that the largest impact on the differential assessment of risk by international agencies comes from policy and judgment, rather than science.
机译：事实证明，风险评估的方法根据不同的假设和所使用的理由，在监管机构之间和跨辖区范围内会有所不同。来自六个国际机构的筛查级风险评估方法被应用于针对苯并[a] py（B [a] P）暴露的城市案例研究，并进行了比较，以深入了解代理方法，假设和方法之间的差异。理由。暴露估计范围是四倍，大部分剂量来自动物产品（8-73％）和植物产品（24-8％）的暴露。各个机构的总癌症风险变化了两个数量级，暴露于空气以及动植物产品对总癌症风险的影响最大，而空气对风险的影响最大（1-99％）。根据流行病学和动物数据的组合或动物数据，选择100倍的癌症风险可归因于毒理学参考值（TRV）的选择。城市暴露途径对癌症风险的贡献和重要性根据TRV的不同而不同，最终根据风险评估假设和指导的差异而有所不同。虽然所有机构风险评估方法均基于科学，但研究结果表明，国际机构对风险差异评估的最大影响来自政策和判断，而非科学。

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