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A Framework and Case Study for Exposure Assessment in the Voluntary Children's Chemical Evaluation Program

机译：儿童自愿性化学评估计划中暴露评估的框架和案例研究

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摘要

A conceptual framework is presented for conducting exposure assessments under the U.S. EPA's Voluntary Children's Chemical Evaluation Program (VCCEP). The VCCEP is a voluntary program whereby companies that manufacture chemicals of potential concern are asked to conduct hazard, exposure, and risk assessments for the chemicals. The VCCEP is unique in its risk-based, tiered approach, and because it focuses on children and requires a comprehensive consideration of all reasonably foreseeable exposure pathways for a particular chemical. The consideration of all potential exposure pathways for some commonly used chemicals presents a daunting challenge for the exposure assessor. This article presents a framework for managing this complicated process, and illustrates the application of the framework with a hypothetical case study. The framework provides guidance for interpreting multiple sources of exposure information and developing a plausible list of exposure pathways for a chemical. Furthermore, the framework provides a means to process all the available information to eliminate pathways of negligible concern from consideration. Finally, the framework provides guidance for utilizing the tiered approach of VCCEP to efficiently conduct an assessment by first using simple, screening-level approaches and then, if necessary, using more complex, refined exposure assessment methods. The case study provides an illustration of the major concepts.
机译：根据美国EPA的《自愿儿童化学评估计划》（VCCEP），提出了用于进行暴露评估的概念框架。 VCCEP是一项自愿计划，要求制造潜在关注化学品的公司对化学品进行危害，暴露和风险评估。 VCCEP的独特之处在于其基于风险的分层方法，因为它关注儿童，并且需要全面考虑特定化学品的所有合理可预见的暴露途径。对于某些常用化学品，考虑所有潜在的暴露途径，对暴露评估人员来说是一个艰巨的挑战。本文提供了一个用于管理此复杂过程的框架，并通过假设的案例研究说明了该框架的应用。该框架为解释多种暴露信息来源和制定合理的化学品暴露途径清单提供了指导。此外，该框架提供了一种处理所有可用信息的方法，从而消除了可忽略不计的关注途径。最后，该框架为使用VCCEP的分层方法有效地进行评估提供了指导，首先使用简单的筛查级方法，然后在必要时使用更复杂的改进的暴露评估方法。案例研究提供了主要概念的说明。

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