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Neurological Soft Signs in Schizophrenia: A Meta-analysis

机译：精神分裂症的神经系统软体征：荟萃分析

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摘要

Background: Neurological soft signs (NSS) are hypothesized as candidate endophenotypes for schizophrenia, but their prevalence and relations with clinical and demographic data are unknown. The authors undertook a quantification (meta-analysis) of the published literature on NSS in patients with schizophrenia and healthy controls. A systematic search was conducted for published articles reporting NSS and related data using standard measures in schizophrenia and healthy comparison groups. Method: A systematic search was conducted for published articles reporting data on the prevalence of NSS in schizophrenia using standard clinical rating scales and healthy comparison groups. Meta-analyses were performed using the Comprehensive Meta-analysis software package. Effect sizes (Cohen d) indexing the difference between schizophrenic patients and the healthy controls were calculated on the basis of reported statistics. Potential moderator variables evaluated included age of patient samples, level of education, sample sex proportions, medication doses, and negative and positive symptoms. Results: A total of 33 articles met inclusion criteria for the meta-analysis. A large and reliable group difference (Cohen d) indicated that, on average, a majority of patients (73%) perform outside the range of healthy subjects on aggregate NSS measures. Cognitive performance and positive and negative symptoms share 2%–10% of their variance with NSS. Conclusions: NSS occur in a majority of the schizophrenia patient population and are largely distinct from symptomatic and cognitive features of the illness.
机译：背景：神经软性体征（NSS）被假定为精神分裂症的候选内表型，但其流行程度以及与临床和人口统计学数据的关系尚不清楚。作者对患有精神分裂症和健康对照的NSS的已发表文献进行了定量（元分析）。对精神分裂症和健康对照组的标准方法，系统地搜索了报告NSS和相关数据的已发表文章。方法：使用标准临床评分量表和健康对照组，系统地搜索发表的报告精神分裂症中NSS患病率数据的文章。使用综合荟萃分析软件包进行荟萃分析。根据报道的统计数据，计算出索引精神分裂症患者与健康对照之间差异的效应大小（Cohen d）。评估的潜在主持人变量包括患者样本的年龄，受教育程度，样本性别比例，药物剂量以及阴性和阳性症状。结果：共有33篇文章符合荟萃分析的纳入标准。可靠的大组差异（Cohen d）表明，平均而言，大多数患者（73％）在总体NSS量表上的表现超出健康受试者的范围。认知能力，阳性和阴性症状与NSS的差异分别为2％–10％。结论：NSS发生在大多数精神分裂症患者人群中，并且与该疾病的症状和认知特征大不相同。

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  • 来源
    《Schizophrenia Bulletin》 |2010年第6期|p.1089-1104|共16页
  • 作者

    Ya Wang;

  • 作者单位

    Institute of Psychology, Chinese Academy of Sciences, 4A Datun Road, Beijing 100101, China;

    tel/fax: +86-0-10-64836274, e-mail:;

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