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首页> 外文期刊>Science of advanced materials >Silver Nanostar Patterned Substrate for Label-Free Characterization of Breast Cancer Cells based on Surface-Enhanced Raman Spectroscopy
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Silver Nanostar Patterned Substrate for Label-Free Characterization of Breast Cancer Cells based on Surface-Enhanced Raman Spectroscopy

机译：基于表面增强拉曼光谱的乳腺癌细胞无标记特征的银纳米星图案化底物

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摘要

Characterization of cancer cells is important in case of personalized cancer therapy. Cells can be characterized based on their surface marker expression level using fluorescence or surface-enhanced Raman spectroscopy (SERS) method, but in both cases its needed additional labeling with fluorescent or Raman dyes, those may cause cellular cytotoxicity. In this study, we report silver (Ag) nanostar pattern modified ITO substrate capable of label free characterization of breast cancer cells based on SERS. The substrate was fabricated by depositing homogeneously distributed silver nanostar pattern on ITO-glass surface electrochemically. The substrate was capable to produce highly intense SERS spectra in comparison to gold nanopattern modified substrate. Two different subtypes of breast cancer cells (SK-BR-3 and MCF-7) were immobilized on the substrate separately and successfully distinguished based on the molecular information detected by SERS. Our newly developed substrate can be used as an effective platform for molecular detection and characterization of different cells originated from same or different organs.
机译：在个性化癌症治疗的情况下，癌细胞的表征很重要。可以使用荧光或表面增强拉曼光谱（SERS）方法根据其表面标志物表达水平来表征细胞，但是在两种情况下都需要用荧光或拉曼染料对其进行额外标记，这可能会引起细胞毒性。在这项研究中，我们报告了银（Ag）纳米星图案修饰的ITO基板，该基板能够基于SERS来标记无标记的乳腺癌细胞。通过在ITO玻璃表面上电化学沉积均匀分布的银纳米星图案来制造基板。与金纳米图案修饰的衬底相比，该衬底能够产生高强度的SERS光谱。将两种不同亚型的乳腺癌细胞（SK-BR-3和MCF-7）分别固定在基质上，并根据SERS检测到的分子信息成功区分出它们。我们新开发的底物可用作分子检测和表征源自相同或不同器官的不同细胞的有效平台。

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  • 来源
    《Science of advanced materials》 |2014年第11期|2491-2495|共5页
  • 作者

    Khaled Hossain; Hyeon-Yeol Cho; Kyeong-Jun Kim; Jeong-Woo Choi;

  • 作者单位

    Interdisciplinary Program of Integrated Biotechnology, Sogang University, 35 Baekbeom-Ro, Mapo-Gu, Seoul, 121-742, Republic of Korea;

    Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-Ro, Mapo-Gu, Seoul, 121-742, Republic of Korea;

    Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-Ro, Mapo-Gu, Seoul, 121-742, Republic of Korea;

    Interdisciplinary Program of Integrated Biotechnology, Sogang University, 35 Baekbeom-Ro, Mapo-Gu, Seoul, 121-742, Republic of Korea ,Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-Ro, Mapo-Gu, Seoul, 121-742, Republic of Korea;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Silver Nanostar; Label-Free Characterization; Breast Cancer Cells; SERS;

    机译：银纳米星;无标签表征;乳腺癌细胞;SERS;

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