首页> 外文期刊>Science and Culture >A 'CRISPR' OVERVIEW OF GENOME EDITING: POTENTIALS AND CHALLENGES
【24h】

A 'CRISPR' OVERVIEW OF GENOME EDITING: POTENTIALS AND CHALLENGES

机译:基因组编辑的“ CRISPR”概述:潜力和挑战

获取原文
获取原文并翻译 | 示例
           

摘要

"CRISPR" stands for Clustered Regularly Interspaced Short Palindromic Repeats, which is the characteristic of a bacterial immune system that forms the basis for the popular CRISPR-Cas9 genome editing technology. It is robust, faster, cheaper and more accurate than previous DNA editing techniques such as meganucleases, zinc finger nucleases (ZFN), and transcription activator like effector nucleases (TALEN). This technology has a wide range of potential applications ranging from basic research, agriculture, biomedicine, generating germline animal models, somatic genome engineering , functional genome screening and in treating genetic diseases. Nowadays CRISPR-Cas9 tool is the most versatile, simplest and precise method of genome editing and is therefore attracting a lot of attention in the scientific world. This review highlights evolution, classification, components and applications of CRISPR based technology as well as its future challenges.
机译:“ CRISPR”代表簇状规则间隔的短回文重复序列,这是细菌免疫系统的特征,构成了流行的CRISPR-Cas9基因组编辑技术的基础。它比以前的DNA编辑技术(如大范围核酸酶,锌指核酸酶(ZFN)和转录激活子(如效应核酸酶)(TALEN))健壮,更快,更便宜,更准确。该技术具有广泛的潜在应用,包括基础研究,农业,生物医学,生成种系动物模型,体细胞基因组工程,功能基因组筛选以及治疗遗传疾病。如今,CRISPR-Cas9工具是最通用,最简单和精确的基因组编辑方法,因此在科学界引起了广泛关注。这篇综述重点介绍了基于CRISPR的技术的发展,分类,组成和应用以及未来的挑战。

著录项

  • 来源
    《Science and Culture》 |2017年第8期|210-220|共11页
  • 作者单位

    National Institute of Biomedical Genomics, Kalyani, West Bengal,India 741251;

    National Institute of Biomedical Genomics, Kalyani, West Bengal,India 741251;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号