Atomic Force Microscopy of Sickle-Shaped RBC

HEENA KOHAD; JAPAN GUHA; RADHABALLAV BHAR; DEEPTI JAIN; VEDACHALAIYER GANESAN

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Atomic Force Microscopy of Sickle-Shaped RBC

机译：镰状红细胞的原子力显微镜

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摘要

The cyto-architecture studies of normal red blood cells (RBCs), using Atomic Force Microscope (AFM), obtained from a hierarchy of species in the course of phylogenetic evolution, ranging from fish to mammals depicted an interesting consensus in their surface membrane structural pattern. In our present investigation, sickle-shaped RBCs of Sickle Cell Anaemia patients are imaged for the first time using AFM, to our knowledge, and their distinct cyto-architecture features are described. Differences in membrane surface structural features are reflection of the emergence of deviated cell type due to genetic anomaly. In sickle-shaped RBCs we observed gross alteration of morphology with cyto-architecture and the altered cyto-architectural pattern of sickle-shaped cells may be related to unknown alteration of membrane properties.

机译：使用原子力显微镜（AFM）对正常红细胞（RBC）进行的细胞结构研究，从鱼类到哺乳动物的系统发育进化过程中，从物种的层次结构中获得，在其表面膜结构模式上描绘了一个有趣的共识。在我们目前的研究中，据我们所知，镰刀形贫血患者的镰刀状RBC首次使用AFM成像，并描述了它们独特的细胞结构特征。膜表面结构特征的差异反映了由于遗传异常而导致的细胞类型出现偏差。在镰刀状的红细胞中，我们观察到细胞结构的形态发生了巨大变化，镰刀状细胞的细胞结构模式改变可能与未知的膜特性改变有关。

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来源
《Science and Culture》 |2012年第6期|p.264-266|共3页
作者
HEENA KOHAD; JAPAN GUHA; RADHABALLAV BHAR; DEEPTI JAIN; VEDACHALAIYER GANESAN;
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作者单位

Biotechnology Department,P.M.B. Gujarati Science College,1, Nasia Road, Indore 452 001, India;

Modern Dental College and Research Centre,Gandhinagar, Indore 453 112, India;

University Science Instrumentation Centre,Jadavpur University, Kolkata 700 032, India;

UGC-DAE Consortium for Scientific Research,University Campus, Khandwa Road, Indore 452 017, India;

UGC-DAE Consortium for Scientific Research,University Campus, Khandwa Road, Indore 452 017, India;

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正文语种 eng
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关键词
sickle cell anaemia; cyto-architecture; ultra-structure; afm;

机译：镰状细胞性贫血细胞结构超结构AFM;

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Atomic Force Microscopy of Sickle-Shaped RBC

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