One-hundredth Year of Recognition of Discovery of Complement Protein

Subrato Ghosh

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One-hundredth Year of Recognition of Discovery of Complement Protein

机译：认识到补体蛋白发现的一百年

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Different cells and molecules in mammalian body, viz. ciliated epithelial cells, macrophages, digestive enzymes, lysozyme, bacteriolysin, transferin, C-reactive protein, complement protein (CP) constitute the first line of defense against pathogens and are components of innate immune system. Complement system (CS) consists of 35 distinct soluble and membrane-associated proteins, circulate in blood and tissue fluids and play crucial role in host defense. Immediately after the pathogen is encountered, in classical pathway, antigen-antibody complex activates the CS; recognition of pathogen-associated molecular pattern (PAMP) by lectins activates CS in lectin pathway and it is activated by cell wall components of pathogen in alternate pathway. Activated components of CS are involved in bacterial lysis, chemotaxis and pathogen opsonization. Once pathogen-specific antibodies are generated, CS aids in clearance of immune complexes and pathogen elimination. Bridging innate and adaptive immune responses functionally, CS allows an integrated defense to invading pathogens, can elicit highly-efficient immune responses, both inflammation and to pathogenic organisms, 'complementing' the antibacterial properties of antibody.

机译：哺乳动物体内的不同细胞和分子，viz。纤毛的上皮细胞，巨噬细胞，消化酶，溶菌酶，溶胶溶胶，转移蛋白，C-反应蛋白，补体蛋白质（CP）构成了对病原体的第一道防护，是先天免疫系统的组分。补体系统（CS）由35个不同的可溶性和膜相关蛋白质组成，在血液和组织液中循环，并在宿主防御中发挥至关重要的作用。在遇到病原体后，在经典途径中，抗原 - 抗体复合物激活CS;通过凝集素识别病原体相关的分子模式（PAMP）在凝集素途径中激活Cs，并通过替代途径的病原体的细胞壁组分激活。 CS的活化组分涉及细菌裂解，趋化性和病原体调理化。一旦产生了病原体特异性抗体，CS助剂在免疫复合物和病原体消除的情况下助理。在功能上桥接先天和自适应免疫应答，CS允许综合防御侵入病原体，可以引发高效的免疫反应，炎症和致病生物，“补充”抗体的抗菌性质。

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《Science and Culture》 |2019年第8期|297-298|共2页
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Subrato Ghosh;
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1. Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway [J] . JacquetM., LacroixM., AnceletS., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2013,第7期

机译：解密补体受体1型与凝集素补体途径的识别蛋白的相互作用
2. Deciphering Complement Receptor Type 1 Interactions with Recognition Proteins of the Lectin Complement Pathway [J] . Micka?l Jacquet, Monique Lacroix, Sarah Ancelet, The journal of immunology . 2013,第7期

机译：与凝集素补体途径的识别蛋白的破译补体受体1型相互作用。
3. Enhanced recognition of plasma proteins in a non-native state by complement C3b. A possible clearance mechanism for damaged proteins in blood [J] . Ramadass Mahalakshmi, Ghebrehiwet Berhane, Kew Richard R. Molecular Immunology . 2015,第1期

机译：补体C3b增强对非天然血浆蛋白的识别。血液中受损蛋白质可能的清除机制
4. GA-Facilitated Knowledge Discovery and Pattern Recognition Optimization Applied to the Biochemistry of Protein Solvation [C] . Michael R. Peterson, Travis E. Doom, Michael L. Raymer Genetic and Evolutionary Computation Conference(GECCO 2004) pt.1; 20040626-630; Seattle,WA(US) . 2004

机译：GA促进的知识发现和模式识别优化在蛋白质溶剂化生物化学中的应用
5. Extending chemical complementation to bacteria and furthering nuclear receptor based protein engineering and drug discovery. [D] . Johnson, Kenyetta A. 2009

机译：将化学互补作用扩展到细菌，并进一步促进基于核受体的蛋白质工程和药物开发。
6. Enhanced recognition of plasma proteins in a non-native state by complement C3b. A possible clearance mechanism for damaged proteins in blood [O] . Mahalakshmi Ramadass, Berhane Ghebrehiwet, Richard R. Kew -1

机译：补体C3b增强对非天然血浆蛋白的识别。血液中受损蛋白质可能的清除机制
7. Deciphering Complement Receptor Type 1 Interactions with Recognition Proteins of the Lectin Complement Pathway [O] . Mickaël Jacquet, Monique Lacroix, Sarah Ancelet, 2013

机译：解入补体受体1型与凝集素补体途径的识别蛋白相互作用

One-hundredth Year of Recognition of Discovery of Complement Protein

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