Analysis for Science Librarians of the 2018 Nobel Prize in Chemistry: Directed Evolution of Enzymes and Phage Display of Peptides and Antibodies

Donna T. Wrublewski

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Analysis for Science Librarians of the 2018 Nobel Prize in Chemistry: Directed Evolution of Enzymes and Phage Display of Peptides and Antibodies

机译：2018年诺贝尔化学奖学科学员的科学员分析：肽和抗体酶和噬菌体展示的定向演变

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The 2018 Nobel Prize in Chemistry recognized three scientists for harnessing evolutionary mechanisms to create molecules capable of new and specific chemical reactions. George Smith and Gregory Winter received one half of this year's Prize for work for developing and utilizing phage display to express proteins and antibodies on molecules that ultimately can be used to make therapeutic phar-maceuticals. Frances Arnold received one half of this year's award for work developing and optimizing the process of directed evolution to create enzymes that catalyze new reactions, which have been used to improve fuel and pesticide production processes, among others. Each of these researchers contributed a key part to the overall advancement of directed chemical synthesis, which continues to create new solutions for problems in fields ranging from Pharmaceuticals to pest control.

机译：2018年诺贝尔化学奖认可三位科学家利用进化机制，以产生能够新的和特异性化学反应的分子。 George Smith和Gregory Winter获得了今年的工作奖的一半，用于开发和利用噬菌体展示，以表达蛋白质和抗体的分子，最终可用于制备治疗性Phar-Maceuticals。 Frances Arnold获得了今年的工作发展奖，并优化了定向演变的过程，以创建催化新反应的酶，这些酶已被用于改善燃料和农药生产过程等。这些研究人员中的每一个都为指导化学合成的总体进步贡献了关键部分，这继续为从药物到害虫控制的田间中的问题产生新的解决方案。

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来源
《Science & Technology Libraries》 |2019年第1期|51-69|共19页
作者
Donna T. Wrublewski;
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作者单位

Caltech Library California Institute of Technology Pasadena CA USA;

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收录信息美国《工程索引》(EI);
原文格式 PDF
正文语种 eng
中图分类
关键词
2018 Nobel Prize in Chemistry; directed evolution; enzymes; phage display; peptides; antibodies; George P. Smith; Sir Gregory P. Winter; Frances H. Arnold;

机译：2018诺贝尔化学奖;定向演变;酶;噬菌体展示;肽;抗体;George P. Smith;格雷戈里先生P.冬天;Frances H. Arnold.;

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1. The 2018 Nobel Prize in Chemistry: phage display of peptides and antibodies [J] . Barderas Rodrigo, Benito-Pena Elena Analytical and bioanalytical chemistry . 2019,第12期

机译：2018年诺贝尔化学奖：肽和抗体的噬菌体展示
2. Directed evolution - bringing the power of evolution to the laboratory: 2018 Nobel Prize in Chemistry (vol 115, pg 1627, 2018) [J] . Verma Sheenam, Salunke Dinakar M. Current Science: A Fortnightly Journal of Research . 2018,第10期

机译：定向的演化 - 将演变的力量带到实验室：2018诺贝尔化学奖（Vol 115，PG 1627,2018）
3. Directed evolution - bringing the power of evolution to the laboratory: 2018 Nobel Prize in Chemistry [J] . Verma Sheenam, Salunke Dinakar M. Current Science: A Fortnightly Journal of Research . 2018,第9期

机译：定向演进 - 将演变力量的力量带到实验室：2018年诺贝尔化学奖
4. Directed evolution of catalytic antibodies in phage-displayed combinatorial libraries [C] . China-Japan-Korea Joint Symposium on Enzyme Engineering . 2004

机译：噬菌体展示组合文库中催化抗体的定向进化
5. Isolation and analysis of peptides binding to helix 69 of E. coli 23 S rRNA from M13 phage display [D] . Kaur, Moninderpal 2011

机译：从M13噬菌体展示中分离和分析与大肠杆菌23 S rRNA螺旋69结合的肽
6. Evolution of three Nobel Prize themes and a Nobel snub theme in chemistry: a bibliometric study with focus on international collaboration [O] . Sichao Tong, Per Ahlgren -1

机译：三个诺贝尔奖主题和一个化学诺贝尔奖主题的演变：以国际合作为重点的文献计量研究
7. The 2018 Nobel Prize in Chemistry: phage display of peptides and antibodies [O] . Rodrigo Barderas, Elena Benito-Peña 2019

机译：2018年诺贝尔化学奖：肽和抗体的噬菌体展示
8. In-situ exploration of Venus on a global scale : direct measurements of origins and evolution, meterology, dynamics, and chemistry by a long-duration aerial science station [R] . Baines, Kevin H., Atreya, Sushi, Carlson, Robert W., 2005

机译：在全球范围内对金星进行现场勘探：通过长期航空科学站直接测量起源和演化，气象学，动力学和化学

Analysis for Science Librarians of the 2018 Nobel Prize in Chemistry: Directed Evolution of Enzymes and Phage Display of Peptides and Antibodies

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