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Portable microcontroller-based electrostimulation system for nerve conduction studies

机译:用于神经传导研究的便携式微控制器的静电刺激系统

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摘要

Despite nerve conduction study (NCS) being an established procedure in the evaluation of neuromuscular disorders, its utility has been restrained by commercially available products or approaches presented in the literature that are either costly, physically large, dependent on specialised medical personnel to operate or targeted to specific conditions, evaluating only one or two nerves. Therefore, the objective of this work was to develop a point-of-care device for NCS that can be used to evaluate several nerves, yet is still portable, low-cost and easy to operate. The developed device is composed of three modules: (i) controller module and graphical user interface, responsible for system synchronisation and configuration, data management, graphical visualisation of the evoked action potential and stimulus voltage feedback (maximum error of 3.92%); (ii) stimulation module, which operates in a constant voltage mode and delivers a monophasic stimulus pulse with amplitudes between 0.84 and 230 V, with a discrete increment of 2.32 +/- 0.64 V (mean +/- SD) and duration of 100 or 200 mu s; and (iii) data acquisition module, based on the ADS1298 front-end that records the evoked action potentials after the stimulus, with a sample rate of 16 or 32 kHz, 24-bit resolution and selectable voltage gain of 1 up to 12. Results demonstrated that the system could reliably deliver stimulation pulses through different loads (100 omega, 1 k omega and 10 k omega) and accurately record data through frequencies of 10 Hz up to 10 kHz. Additionally, NCS of the ulnar motor nerve in a sample of healthy individuals showed that the device could effectively activate a peripheral nerve and record compound action potentials within normal limits established by the literature.
机译:尽管神经传导研究(NCS)是在评估神经肌肉障碍的既定程序中,但其公用设施已受到商业上可获得的产品或方法,这些产品或昂贵的产品或昂贵的物理大,依赖专门的医务人员来运营或有针对性对特定条件,仅评估一个或两个神经。因此,这项工作的目的是为能够用于评估若干神经的NCS开发护理点装置,但仍然是便携式,低成本且易于操作的。开发设备由三个模块组成:(i)控制器模块和图形用户界面,负责系统同步和配置,数据管理,诱发动作电位的图形可视化和刺激电压反馈(最大误差为3.92%); (ii)刺激模块以恒定的电压模式操作,并在0.84和230 V之间提供具有幅度的单表刺激脉冲,其离散增量为2.32 +/- 0.64 V(平均+/-SD)和100或100 200亩; (iii)数据采集模块,基于ADS1298前端记录刺激后诱发的动作电位,采样率为16或32 kHz,24位分辨率和1至12的可选电压增益。结果证明系统可以通过不同的负载(100 omega,1 k Omega和10 k Omega)可靠地传递刺激脉冲,并通过10 Hz的频率准确地记录数据,最高可达10 kHz。另外,健康个体样本中的尺尺神经中的NCS在健康的个体样本中表明该装置可以有效地激活周围神经并在文献建立的正常限制内记录复合作用电位。

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