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首页> 外文期刊>The Science of the Total Environment >Levels of polycyclic aromatic hydrocarbons in umbilical cord and risk of orofacial clefts
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Levels of polycyclic aromatic hydrocarbons in umbilical cord and risk of orofacial clefts

机译：脐带中多环芳烃的含量和口唇裂的风险

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摘要

Polycyclic aromatic hydrocarbons (PAHs), which are ubiquitous in the environment, have been found to cause orofacial clefts (OFCs) in mouse model. However, evidence from the human study with markers of intrauterine exposure is absent. We explored the associations between the levels of sixteen PAHs in umbilical cord tissue and risk for OFCs using multivariable logistic models and Bayesian Kernel Machine Regression (BKMR). This case-control study included 89 OFC cases and 129 controls without congenital malformations. Concentrations of PAHs in umbilical cord tissue were detected using gas chromatography coupled to triple quadrupole tandem mass spectrometry. The median levels of Sigma PAHs, Sigma low molecular weight polycyclic aromatic hydrocarbons, and Sigma high molecular weight polycyclic aromatic hydrocarbons were all higher in cases of total OFCs and its subtypes than in controls, although the differences were not statistically significant. No statistical associations between levels of PAHs in umbilical cord tissue and risk for OFCs were observed in either multivariable logistic models or BKMR models. Maternal using a stove for heating and lower frequency of ventilation in the bedroom/living room, and consumptions of fresh green vegetables were positively correlated with levels of PAHs in umbilical cord. In conclusion, our results did not suggest that in utero exposure to PAHs were associated with the risk for OFCs, in estimating whether single effect of PAHs or joint effects of multiple PAHs. (C) 2019 Elsevier B.V. All rights reserved.
机译：在环境中普遍存在的多环芳烃（PAH）在小鼠模型中会引起口唇裂（OFC）。但是，缺乏来自人体研究的具有宫内暴露标记的证据。我们使用多变量逻辑模型和贝叶斯核机器回归（BKMR）探索了脐带组织中16种PAHs水平与OFC风险之间的关联。这项病例对照研究包括89例OFC病例和129例无先天性畸形的对照。使用与三重四极杆串联质谱联用的气相色谱法检测脐带组织中PAHs的浓度。在总OFC及其亚型的情况下，Sigma PAHs，Sigma低分子量多环芳烃和Sigma高分子量多环芳烃的中位水平均高于对照组，尽管差异无统计学意义。在多变量logistic模型或BKMR模型中，未观察到脐带组织中PAHs水平与OFC风险之间的统计关联。孕妇在卧室/起居室中使用炉子加热和降低通风频率，新鲜绿色蔬菜的消费与脐带PAHs水平呈正相关。总之，我们的研究结果并不表明子宫内暴露于PAHs与OFCs的风险有关，在评估PAHs的单一作用还是多种PAHs的联合作用方面。 （C）2019 Elsevier B.V.保留所有权利。

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  • 来源
    《The Science of the Total Environment》 |2019年第15期|123-132|共10页
  • 作者

    Ni Wenli; Yang Wenlei; Jin Lei; Liu Jufen; Li Zhiwen; Wang Bin; Wang Linlin; Ren Aiguo;

  • 作者单位

    Peking Univ, Natl Hlth Commiss, Dept Epidemiol & Biostat,Key Lab Reprod Hlth, Sch Publ Hlth,Inst Reprod & Child Hlth,Hlth Sci C, Beijing, Peoples R China;

    Peking Univ, Natl Hlth Commiss, Dept Epidemiol & Biostat,Key Lab Reprod Hlth, Sch Publ Hlth,Inst Reprod & Child Hlth,Hlth Sci C, Beijing, Peoples R China;

    Peking Univ, Natl Hlth Commiss, Dept Epidemiol & Biostat,Key Lab Reprod Hlth, Sch Publ Hlth,Inst Reprod & Child Hlth,Hlth Sci C, Beijing, Peoples R China;

    Peking Univ, Natl Hlth Commiss, Dept Epidemiol & Biostat,Key Lab Reprod Hlth, Sch Publ Hlth,Inst Reprod & Child Hlth,Hlth Sci C, Beijing, Peoples R China;

    Peking Univ, Natl Hlth Commiss, Dept Epidemiol & Biostat,Key Lab Reprod Hlth, Sch Publ Hlth,Inst Reprod & Child Hlth,Hlth Sci C, Beijing, Peoples R China;

    Peking Univ, Natl Hlth Commiss, Dept Epidemiol & Biostat,Key Lab Reprod Hlth, Sch Publ Hlth,Inst Reprod & Child Hlth,Hlth Sci C, Beijing, Peoples R China;

    Peking Univ, Natl Hlth Commiss, Dept Epidemiol & Biostat,Key Lab Reprod Hlth, Sch Publ Hlth,Inst Reprod & Child Hlth,Hlth Sci C, Beijing, Peoples R China;

    Peking Univ, Natl Hlth Commiss, Dept Epidemiol & Biostat,Key Lab Reprod Hlth, Sch Publ Hlth,Inst Reprod & Child Hlth,Hlth Sci C, Beijing, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Polycyclic aromatic hydrocarbons; Orofacial clefts; Umbilical cord tissue; Bayesian Kernel Machine Regression;

    机译：多环芳烃;面裂;脐带组织;贝叶斯核回归;

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