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首页> 外文期刊>The Science of the Total Environment >Thyroid endocrine status of wild European eels (Anguilla anguilla) in the Loire (France). Relationships with organic contaminant body burdens
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Thyroid endocrine status of wild European eels (Anguilla anguilla) in the Loire (France). Relationships with organic contaminant body burdens

机译：卢瓦尔河（法国）的野生欧洲鳗鱼（安圭拉安圭拉）的甲状腺内分泌状况。与有机污染物身体负担的关系

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In teleost fish, thyroid function is involved in various critical physiological processes. Given the complexity of the hypothalamo-pituitary-thyroid (HPT) axis, a large number of genes and proteins can be the potential target of endocrine-disrupting compounds (EDCs). The aim of this study was to evaluate, in yellow and silver European eels (Anguilla anguilla). potential effects of EDCs on thyroid status by analyzing the associations between EDC body burdens and thyroid hormones (THs). In yellow individuals, greater free T3/T4 ratios (FT3/FT4) and lower plasma FT4 levels were associated with greater concentrations of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), as highlighted by significant correlations with many congeners. Few positive relationships with alkylphenols were noticed. In contrast, silver eels usually exhibited less significant correlations between THs and contaminant loads. Expression of a series of genes involved in the HPT axis was also investigated in the silver individuals. Concerning mRNA expression in silver females, some main correlations were noticed: thyroid-stimulating hormone (TSHβ) gene expression was significantly correlated to numerous PCBs, and hepatic mRNA levels of deiodinase 2 (Deio 2) were negatively correlated to 2-hydroxyfluorene (2-OHF) and 2-naphtol (2-OHNa). Thyroid receptor (TRα and TRβ) mRNA levels exhibited weak negative correlations with some PBDEs in silver females and males. Hepatic vitellogenin (Vtg) mRNA levels were detected in all silver males but at lower levels than in silver females. In males, Vtg mRNA levels were positively assodated to FT4/TT4. In silver females, strong positive correlations were found between congeners of PCBs, PBDEs and PFAS suggesting potential estrogenic effects. Overall, the observed results indicate that several organic contaminants, mainly dl- ndl-PCBs and PBDEs, could be associated with changes in thyroid homeostasis in these fish, via direct or indirect interactions with peripheral deiodination, metabolism of T4 and mechanisms involved in TSHβ, Deio 2 and Vtg gene transcription.
机译：在硬骨鱼中，甲状腺功能涉及各种关键的生理过程。考虑到下丘脑-垂体-甲状腺（HPT）轴的复杂性，大量基因和蛋白质可能成为破坏内分泌的化合物（EDC）的潜在靶标。这项研究的目的是评估黄色和银色的欧洲鳗鱼（安圭拉鳗鱼）。通过分析EDC身体负担与甲状腺激素（THs）之间的联系，了解EDC对甲状腺状况的潜在影响。在黄色个体中，较高的游离T3 / T4比（FT3 / FT4）和较低的血浆FT4水平与较高浓度的多氯联苯（PCB）和多溴联苯醚（PBDEs）相关，这与许多同类物具有显着相关性。与烷基酚的正相关关系很少。相比之下，银鳗通常在TH和污染物负荷之间的相关性较低。还在银个体中研究了涉及HPT轴的一系列基因的表达。关于银母中的mRNA表达，注意到一些主要相关性：甲状腺刺激激素（TSHβ）基因表达与大量PCB显着相关，而脱碘酶2（Deio 2）的肝mRNA水平与2-羟基芴（2- OHF）和2-萘酚（2-OHNa）。雌性和雄性中，甲状腺受体（TRα和TRβ）的mRNA水平与某些PBDEs呈弱的负相关。在所有男性银中检测到肝卵黄蛋白原（Vtg）mRNA水平，但低于女性银。在男性中，Vtg mRNA水平与FT4 / TT4呈正相关。在银雌性动物中，发现多氯联苯，多溴二苯醚和全氟辛烷磺酸的同类物之间有很强的正相关，表明潜在的雌激素作用。总体而言，观察到的结果表明，几种有机污染物（主要是dl-ndl-PCBs和PBDEs）可能与这些鱼类的甲状腺稳态变化有关，这可能是由于其与周围碘的直接或间接相互作用，T4的代谢和TSHβ参与的机制引起的， Deio 2和Vtg基因转录。

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