Synaptic mechanisms of pattern completion in the hippocampal CA3 network

Guzman Segundo Jose; Schloegl Alois; Frotscher Michael; Jonas Peter

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Synaptic mechanisms of pattern completion in the hippocampal CA3 network

机译：海马CA3网络中模式完成的突触机制

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The hippocampal CA3 region plays a key role in learning and memory. Recurrent CA3-CA3 synapses are thought to be the subcellular substrate of pattern completion. However, the synaptic mechanisms of this network computation remain enigmatic. To investigate these mechanisms, we combined functional connectivity analysis with network modeling. Simultaneous recording from up to eight CA3 pyramidal neurons revealed that connectivity was sparse, spatially uniform, and highly enriched in disynaptic motifs (reciprocal, convergence, divergence, and chain motifs). Unitary connections were composed of one or two synaptic contacts, suggesting efficient use of postsynaptic space. Real-size modeling indicated that CA3 networks with sparse connectivity, disynaptic motifs, and single-contact connections robustly generated pattern completion. Thus, macro-and microconnectivity contribute to efficient memory storage and retrieval in hippocampal networks.

机译：海马CA3区在学习和记忆中起关键作用。复发的CA3-CA3突触被认为是模式完成的亚细胞底物。但是，这种网络计算的突触机制仍然是个谜。为了研究这些机制，我们将功能连接分析与网络建模相结合。从多达8个CA3锥体神经元的同时记录显示，连通性稀疏，空间均匀，并且高度富含突触基序（相互，会聚，发散和链状）。单一连接由一个或两个突触接触组成，表明有效利用突触后空间。实际大小的建模表明，具有稀疏连接性，突触主题和单触点连接的CA3网络稳健地生成了模式完成。因此，宏连接和微连接有助于海马网络中有效的内存存储和检索。

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《Science》 |2016年第6304期|1117-1123|共7页
作者
Guzman Segundo Jose; Schloegl Alois; Frotscher Michael; Jonas Peter;
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IST Austria Inst Sci & Technol Austria, Campus 1, A-3400 Klosterneuburg, Austria;

IST Austria Inst Sci & Technol Austria, Campus 1, A-3400 Klosterneuburg, Austria;

Ctr Mol Neurobiol Hamburg, Falkenried 94, D-20251 Hamburg, Germany;

IST Austria Inst Sci & Technol Austria, Campus 1, A-3400 Klosterneuburg, Austria;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Synaptic conditions for auto-associative memory storage and pattern completion in Jensen et al.'s model of hippocampal area CA3 [J] . Eng Yeow Cheu, Jiali Yu, Chin Hiong Tan, Journal of Computational Neuroscience . 2012,第3期

机译：在Jensen等人的海马区CA3模型中，自动联想记忆和模式完成的突触条件
2. Pattern separation and completion of distinct axonal inputs transmitted via micro-tunnels between co-cultured hippocampal dentate, CA3, CA1 and entorhinal cortex networks [J] . Daniele Poli, Bruce C Wheeler, Thomas B DeMarse, Journal of neural engineering . 2018,第4期

机译：通过共培养海马齿状，CA3，CA1和内嗅皮层网络之间的微通道传输的轴突输入的模式分离和完成
3. Cholinergic suppression of glutamatergic synaptic transmission in hippocampal region CA3 exhibits laminar selectivity: Implication for hippocampal network dynamics. [J] . Kremin T, Hasselmo ME Neuroscience: An International Journal under the Editorial Direction of IBRO . 2007,第4期

机译：海马CA3区谷氨酸能突触传递的胆碱能抑制表现出层流选择性：对海马网络动力学的影响。
4. Defining time in a minimal hippocampal CA3 model by matching time-span of associative synaptic modification and input pattern duration [C] . Mitman, K.E., Laurent, . 2003

机译：通过匹配关联突触修饰的时间跨度和输入模式持续时间来定义最小海马CA3模型中的时间
5. Adrenergic receptor modulation of hippocampal CA3 network activity. [D] . Jurgens, Christopher W.D. 2009

机译：肾上腺素受体调节海马CA3网络活动。
6. Pattern separation and completion of distinct axonal inputs transmitted via micro-tunnels between co-cultured hippocampal dentate CA3 CA1 and entorhinal cortex networks [O] . Daniele Poli, Bruce C. Wheeler, Thomas B. DeMarse, -1

机译：通过共培养海马齿状CA3CA1和内嗅皮层网络之间的微通道传输的轴突输入的模式分离和完成
7. Cholinergic suppression of glutamatergic synaptic transmission in hippocampal region CA3 exhibits laminar selectivity: Implication for hippocampal network dynamics [O] . T. Kremin, M.E. Hasselmo 2007

机译：海马区谷氨酸突触突触传递的胆碱能抑制表现出层层选择性：对海马网络动力学的影响

Synaptic mechanisms of pattern completion in the hippocampal CA3 network

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