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首页> 外文期刊>Science >Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors
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Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors

机译：功能蛋白质组学鉴定角质蛋白为AMPA受体的辅助亚基

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摘要

Glutamate receptors of the AMPA-subtype (AMPARs), together with the transmembrane AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the mammalian brain. Here, we show by proteomic analysis that the majority of AMPARs in the rat brain are coassembled with two members of the cornichon family of transmembrane proteins, rather than with the TARPs. Coassembly with cornichon homologs 2 and 3 affects AMPARs in two ways: Cornichons increase surface expression of AMPARs, and they alter channel gating by markedly slowing deactivation and desensitization kinetics. These results demonstrate that cornichons are intrinsic auxiliary subunits of native AMPARs and provide previously unknown molecular determinants for glutamatergic neurotransmission in the central nervous system.
机译：AMPA亚型的谷氨酸受体（AMPAR）与跨膜AMPAR调节蛋白（TARP）共同介导哺乳动物大脑中快速的兴奋性突触传递。在这里，我们通过蛋白质组学分析表明，大鼠大脑中的大多数AMPAR与角质膜家族跨膜蛋白的两个成员共同组装，而不是与TARP组装在一起。与角蛋白同源物2和3的共装配以两种方式影响AMPAR：角蛋白增加AMPAR的表面表达，并且它们通过显着减慢失活和脱敏动力学来改变通道门控。这些结果表明角蛋白是天然AMPAR的固有辅助亚基，并为中枢神经系统中的谷氨酸能神经传递提供了以前未知的分子决定簇。

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  • 来源
    《Science》 |2009年第5919期|1313-1319|共7页
  • 作者

    Jochen Schwenk; Nadine Harmel; Gerd Zolles; Wolfgang Bildl; Akos Kulik; Bernd Heimrich; Osamu Chisaka; Peter Jonas; Uwe Schulte; Bernd Fakler; Nikolaj Kloecker;

  • 作者单位

    Institute of Physiology II, University of Freiburg, Engesserstrasse 4,79108 Freiburg, Germany;

    Institute of Physiology II, University of Freiburg, Engesserstrasse 4,79108 Freiburg, Germany;

    Institute of Physiology II, University of Freiburg, Engesserstrasse 4,79108 Freiburg, Germany;

    Institute of Physiology II, University of Freiburg, Engesserstrasse 4,79108 Freiburg, Germany;

    Institute of Anatomy and Cell Biology, University of Freiburg, Albertstrasse 23,79104 Freiburg, Germany;

    Institute of Anatomy and Cell Biology, University of Freiburg, Albertstrasse 23,79104 Freiburg, Germany;

    Department of Cell and Developmental Biology, Kyoto University, Kyoto 606-8502, Japan;

    Institute of Physiology I, University of Freiburg, Engesserstrasse 4, 79108 Freiburg, Germany;

    Institute of Physiology II, University of Freiburg, Engesserstrasse 4,79108 Freiburg, Germany Logopharm GmbH, Engesserstrasse 4, 79108 Freiburg, Germany;

    Institute of Physiology II, University of Freiburg, Engesserstrasse 4,79108 Freiburg, Germany Center for Biological Signaling Studies (bioss), Albertstrasse 10, 79104 Freiburg, Germany;

    Institute of Physiology II, University of Freiburg, Engesserstrasse 4,79108 Freiburg, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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