Activation of the Protein kinase p38 in the Spindle Assembly Checkpoint and Mitotic Arrest

Katsuya Takenaka; Tetsuo Moriguchi; Eisuke Nishida

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Activation of the Protein kinase p38 in the Spindle Assembly Checkpoint and Mitotic Arrest

机译：主轴装配检查点和有丝分裂逮捕中蛋白激酶p38的激活

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The mitogen-activated protein kinase (MAPK) superfamily comprises classical MAPK (also called ERK), c-Jun amino-terminal or stress-activated protein kinase (JNK or SAPK), and p38. Although MAPK is essential for meiotic processes in Xenopus oocytes and the spindle assembly checkpoint in Xenopus egg extracts, the role of members of the MAPK superfamily inM phase or the spindle assembly checkpoint during somatic cell cycles has not been elucidated. The kinse p38, but not MAPK or JNK, was activated in mammalian cultured cells when the cells were arrested in M phase by disruption of the spindle with nocodazole.

机译：丝裂原激活的蛋白激酶（MAPK）超家族包括经典MAPK（也称为ERK），c-Jun氨基末端或应激激活的蛋白激酶（JNK或SAPK）和p38。尽管MAPK对于非洲爪蟾卵母细胞的减数分裂过程和非洲爪蟾卵提取物中的纺锤体组装检查点至关重要，但尚未阐明MAPK超家族成员在M期或体细胞周期中纺锤体组装检查点的作用。当哺乳动物细胞中的诺考达唑破坏纺锤体使细胞停滞在M期时，激酶p38而不是MAPK或JNK被激活。

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《Science》 |1998年第5363期|p.599-602|共4页
作者
Katsuya Takenaka; Tetsuo Moriguchi; Eisuke Nishida;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint [J] . Agnieszka Kaczmarczyk, Aisling OConnor, Michael D. Rainey, Biology Open . 2016,第1期

机译：维持健壮的主轴组件检查点对PLK1激酶活性的要求维持健壮的主轴组件检查点对PLK1激酶活性的要求维持健壮的主轴组件检查点对PLK1激酶活性的要求
2. Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: implication for carcinogenesis. [J] . Wang YC, Tsai YS, Huang JL, Oral oncology . 2010,第4期

机译：槟榔碱通过放松有丝分裂纺锤体的组装和纺锤体的组装检查点而将细胞停在前中期：对致癌作用的暗示。
3. 6,7-dimethoxy-3-(3-methoxyphenyl)isoquinolin-1-amine induces mitotic arrest and apoptotic cell death through the activation of spindle assembly checkpoint in human cervical cancer cells [J] . ChungK.-S., ChoiH.-E., ShinJ.-S., Carcinogenesis . 2013,第8期

机译：6,7-二甲氧基-3-（3-甲氧基苯基）异喹啉-1-胺通过激活人宫颈癌细胞中的纺锤体装配检查点诱导有丝分裂阻滞和凋亡性细胞死亡
4. Role of G proteins and the p38 Mitogen Activated Protein (MAP) kinase in Lipopolysaccharide (LPS)- induced signaling in human endothelial cells (EC) [C] . Moshe Arditi. Aninda Das, Yiping Jin NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：G蛋白和P38丝裂原活化蛋白（MAP）激酶在人内皮细胞（EC）中的信号传导中的G蛋白和P38丝裂原激活蛋白（MAP）激酶的作用
5. The role of mitogen activated protein kinase activated protein kinase-2 in regulating p38 mitogen activated protein kinase induced cyclooxygenase-2 induction and heart failure. [D] . Streicher, John Michael. 2009

机译：促分裂原激活蛋白激酶激活蛋白激酶2在调节p38促分裂原激活蛋白激酶诱导的环氧合酶2和心力衰竭中的作用。
6. Taxifolin Enhances Andrographolide-Induced Mitotic Arrest and Apoptosis in Human Prostate Cancer Cells via Spindle Assembly Checkpoint Activation [O] . Zhong Rong Zhang, Mazen Al Zaharna, Matthew Man-Kin Wong, 2010

机译：Taxifolin通过纺锤体组装检查点激活增强穿心莲内酯诱导的人前列腺癌细胞的有丝分裂逮捕和凋亡。
7. Heat shock‐induced mitotic arrest requires heat shock protein 105 for the activation of spindle assembly checkpoint [O] . Ayana Kakihana, Yui Oto, Youhei Saito, 2018

机译：热休克诱导的有丝分裂停止需要热休克蛋白105用于激活主轴组件检查点

Activation of the Protein kinase p38 in the Spindle Assembly Checkpoint and Mitotic Arrest

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