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Fertility Treatment Fallout

机译:生育治疗的后果

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S.K. Feuer et al., "Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes," Endocrinology, 155:4554-67,2014. Embryos formed by in vitro fertilization (IVF) experience very different early conditions from naturally conceived embryos. In previous studies, Paolo Rinaudo of the University of California, San Francisco, and colleagues observed that IVF-conceived female mice were more insulin resistant and metabolized glucose poorly compared to normally conceived females, and that IVF mice of both sexes showed altered gene expression, which led them to wonder what might cause such lasting metabolic and transcriptional changes.
机译:S.K. Feuer等人,“体外受精(IVF)对成年小鼠脂肪和肝脏代谢组的性二态影响”,《内分泌学》,155:4554-67,2014。通过体外受精(IVF)形成的胚胎经历的早期条件与自然受孕的胚胎完全不同。在先前的研究中,加利福尼亚大学旧金山分校的Paolo Rinaudo及其同事观察到,与正常怀孕的雌性相比,IVF怀孕的雌性小鼠的胰岛素抵抗力和代谢葡萄糖差,并且两性的IVF小鼠均显示出基因表达改变,这使他们想知道什么可能导致这种持久的代谢和转录变化。

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