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Banking on iPSCs

机译:在iPSC上存款

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About four years ago, Jay Tischfield, the director of RUCDR Infinite Biologics, a long-standing biorepository at Rutgers University, found himself sitting on a gold mine. RUCDR had recently gotten into the business of banking and distributing induced pluripotent stem cell (iPSC) lines. This was still early days in iPSC derivation, only a few years after scientists had figured out how to turn skin cells into cells capable of differentiating into a wide variety of different cell types. But not long into this new endeavor, "something important happened in the field," Tischfield recalls. Researchers reported that they could induce pluripotency from blood cells. It just so happened that RUCDR was in possession of a massive collection of blood cell lines, each with a heap of information on the donor. "There we were, standing on what is perhaps one of the world's, if not the world's, largest collection of genetically defined... lymphocytes from literally almost a half a million subjects," he says. "And it turned out these were fantastic for making iPSCs." Suddenly, the opportunities for iPSC derivation and banking seemed endless.
机译:大约四年前,罗格斯大学(Rutgers University)长期存在的生物存储库RUCDR Infinite Biologics的主任杰伊·蒂斯菲尔德(Jay Tischfield)发现自己坐在一座金矿上。 RUCDR最近涉足银行业务和分销诱导多能干细胞(iPSC)品系。在iPSC推导中还处于早期阶段,仅在科学家们弄清楚如何将皮肤细胞转变为能够分化为多种不同细胞类型的细胞后几年。 Tischfield回忆说,但是在这项新工作不久之后,“该领域发生了重要的事情”。研究人员报告说,它们可以诱导血细胞的多能性。碰巧的是,RUCDR拥有大量的血细胞系集合,每个系都有关于供体的大量信息。他说:“在那里,我们站在了可能是世界上(如果不是世界上)最大的集合中,从字面上将近五十万个受试者那里获得的基因定义的……淋巴细胞中最大的一个。” “事实证明,这些对于制造iPSC而言非常了不起。”突然间,iPSC衍生和银行业务的机会似乎层出不穷。

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    《The Scientist》 |2014年第9期|3234|共2页
  • 作者

    KERRY GRENS;

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