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HLA-INDEXED REPOSITORY OF iPSCS AND iPSC-DERIVED STEM CELLS, AND RELATED SYSTEMS AND METHODS

机译：HLA指示的iPSCS和iPSC衍生干细胞的储存库以及相关系统和方法

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摘要

Described herein is a managed, indexed repository of hematopoietic stem cell (HSC) lines and/or blood progenitor cell lines derived from induced pluripotent stem cells (iPSCs) (or embryoid bodies formed from iPSCs), wherein each of the HSC lines, blood progenitor cell lines, embryoid bodies, and/or iPSC lines has corresponding data comprising a set of characterized HLA loci, said corresponding data being stored in a searchable database for retrieval of one or more matching physical cell lines upon query. The repository comprises an HLA-indexed bank of iPSCs, embryoid bodies, HSCs, and/or blood progenitor cells for each of a set of HLA types, for identification and provision of allogeneic cell lines suitable for transplantation to reestablish hematopoietic function in patients with damaged, diseased, or otherwise abnormal bone marrow and/or immune system.

机译：本文描述了从诱导多能干细胞（iPSC）（或由iPSC形成的胚状体）衍生的造血干细胞（HSC）系和/或血液祖细胞系的受控索引库，其中每个HSC系，血液祖细胞细胞系，胚状体和/或iPSC系具有包含一组特征化的HLA基因座的相应数据，所述相应数据存储在可搜索的数据库中，以在查询时检索一个或多个匹配的物理细胞系。该信息库包含一组HLA索引的iPSC，类胚体，HSC和/或血液祖细胞的HLA索引库，用于鉴定和提供适用于移植的异基因细胞系，以在受损患者中重建造血功能，疾病或其他异常的骨髓和/或免疫系统。

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公开/公告号US2020051666A1

专利类型
公开/公告日2020-02-13

原文格式PDF
申请/专利权人 ORIG3N INC.;
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申请/专利号US201816492690
发明设计人 ROBIN Y. SMITH;MARCIE A. GLICKSMAN;
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申请日2018-03-14
分类号G16B35/20;A61K35/28;A61K35/545;G06F16/22;C12N5/074;C40B40/02;G16H50/70;G16H50/20;
国家 US
入库时间 2022-08-21 11:23:48

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