C. elegans cell lineage, circa 1981

Elie Dolgin

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C. elegans cell lineage, circa 1981

机译：秀丽隐杆线虫细胞谱系，约1981年

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Starting in 1980, John Sulston spent 18 months hunched over a microscope watching Caenorhabditis elegans embryos divide. Together with Bob Horvitz at the Laboratory of Molecular Biology in Cambridge, England, he had already mapped the fate of every cell in the adult worm from the moment the egg hatched, but the embryonic cell lineage remained elusive. Many labs had tried and failed to study the developing embryos using photography, so Sulston figured he would do it by hand. "We all felt that there would be a way [to use photography] someday, but we needed the information now," he says.rnIn these drawings, from May 22,1981, Sulston drew the positions of the cell nuclei, using color to show depth - red on top, green in the middle, and black on the bottom. The long strings of lower-case letters are unique identifying tags that Sulston used to track the different cell lineages.

机译：从1980年开始，约翰·苏尔斯顿（John Sulston）在显微镜下弯腰驼背18个月，观察秀丽隐杆线虫的胚胎分裂。他已经与位于英国剑桥的分子生物学实验室的鲍勃·霍维茨（Bob Horvitz）一起，从卵孵化开始就绘制了成虫中每个细胞的命运图，但是胚胎细胞谱系仍然难以捉摸。许多实验室曾尝试并未能通过摄影研究正在发育的胚胎，所以苏尔斯顿想他会手工完成。他说：“我们总有一天会有一种使用摄影的方法，但是我们现在需要这些信息。”在这些画中，苏尔斯顿从1981年5月22日开始绘制细胞核的位置，使用颜色显示深度-顶部为红色，中间为绿色，底部为黑色。长长的小写字母字符串是Sulston用来跟踪不同细胞谱系的独特识别标签。

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《Scientist》 |2008年第6期|92|共1页
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Elie Dolgin;
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C. elegans cell lineage, circa 1981

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