Leukemia and Cancer Stem Cells

Irving Weissman; Michael Clarke

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Leukemia and Cancer Stem Cells

机译：白血病和癌症干细胞

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Cancers and normal tissue stem cells have much in common: Both have self-renewal capacity, and both develop into differentiated progeny. But do true cancer stem cells exist? We believe that they do and that this realization will have a major impact on the understanding and treatment of cancers. Putative cancer stem cells can be recognized by three attributes: They constitute a homogenous cell population; they, on their own, can initiate cancer; and they both self-renew and undergo differentiation into nontumorigenic progeny.

机译：癌症和正常组织干细胞有很多共同点：两者都具有自我更新的能力，并且都可以分化为后代。但是，真正的癌症干细胞存在吗？我们相信他们会这样做，并且这种认识将对癌症的理解和治疗产生重大影响。推定的癌症干细胞可以通过三个属性来识别：它们构成同质细胞群；他们自己可以引发癌症；它们都自我更新并分化为非致瘤性后代。

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来源
《The Scientist》 |2006年第4期|p.35-36|共2页
作者
Irving Weissman; Michael Clarke;
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作者单位

Stanford's Institute of Stem Cell Biology and Regenerative Medicine;

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正文语种 eng
中图分类自然科学总论;
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6. The PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells [O] . Ömer H. Yilmaz, Sean J. Morrison -1

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7. Friend leukemia virus integration 1 is a predictor of poor prognosis of breast cancer and promotes metastasis and cancer stem cell properties of breast cancer cells [O] . Xu Yan, Yu Yu, Lingyu Li, 2018

机译：朋友白血病病毒整合1是乳腺癌预后不良的预测因子，促进乳腺癌细胞的转移和癌症干细胞性质

Leukemia and Cancer Stem Cells

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