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The Quest for Pain Relief

机译：寻求止痛药

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In the 19th century, the European beaver (Castor fiber) was headed toward extinction. The search for pain relief was one of the reasons why. Beavers were hunted for, among other things, castoreum-a smelly secretion known to have analgesic and anti-inflammatory properties. Castoreum's benefits, subsequent analysis has shown, came from salicin derived from the willow bark in the beaver's diet. For those interested in improving modalities of pain relief today, it's perhaps galling to see just how just how little the field has progressed beyond hunting beavers. In light of the huge global burden of under-treated pain, a question worth asking is where the best hope lies for developing better pain treatment modalities.
机译：在19世纪，欧洲海狸（Castor纤维）走向灭绝。寻求缓解疼痛的原因之一。搜寻海狸的原因之一是海狸-臭皮分泌物，已知具有止痛和抗炎特性。后来的分析表明，Castoreum的好处来自海狸饮食中柳树皮中提取的水杨素。对于那些对今天改善疼痛缓解方式感兴趣的人来说，看到野外捕猎海狸的进展几乎是一件令人振奋的事情。鉴于未得到充分治疗的巨大全球负担，值得提出的问题是开发更好的疼痛治疗方法的最大希望所在。

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