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Uniform-temperature, microscale thermal modulator with area-adjusted air-gap isolation for comprehensive two-dimensional gas chromatography

机译:均温,微型热调节器,具有可调节的气隙隔离,可进行全面的二维气相色谱分析

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摘要

In comprehensive two-dimensional gas chromatography (GC × GC), thermal modulation is an important process to enhance the detectability of a volatile organic compound analyte and compound separation capacity. For increased detectability, we explore a method to enhance the temperature uniformity of a microfabricated thermal modulator with an area-adjusted air-gap spacer. The area-adjusted spacer controls the spatial distribution of heat transfer to increase the temperature uniformity of the analyte passing through the device's channel. This enables higher analyte peak-amplitude enhancement (PAE) during thermal modulation, thereby increasing detectability of the analyte. The influence of varying spacer area on temperature uniformity was characterized by simulation, and its effect on PAE was experimentally estimated. With an optimized spacer design, we achieved a 25% increase in PAE (34-42) for l0 ppm n-octane vapor.
机译:在全面的二维气相色谱(GC×GC)中,热调节是提高挥发性有机化合物分析物的检测能力和化合物分离能力的重要过程。为了提高可检测性,我们探索了一种使用面积可调的气隙垫片来提高微型热调制器温度均匀性的方法。面积调整的垫片控制传热的空间分布,以增加通过设备通道的分析物的温度均匀性。这样可以在热调制过程中实现更高的分析物峰幅度增强(PAE),从而提高了分析物的可检测性。通过模拟表征了变化的垫片面积对温度均匀性的影响,并通过实验估计了其对PAE的影响。通过优化的垫片设计,对于10 ppm正辛烷蒸气,我们的PAE(34-42)提高了25%。

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