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首页> 外文期刊>IEEE sensors journal >Towards a Low-Cost and Portable Photoacoustic Microscope for Point-of-Care and Wearable Applications
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Towards a Low-Cost and Portable Photoacoustic Microscope for Point-of-Care and Wearable Applications

机译：朝向低成本和便携式光声显微镜，用于护理点和可穿戴应用

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摘要

Several breakthrough applications in biomedical imaging have been reported in the recent years using advanced photoacoustic microscopy imaging systems. While two-photon and other optical microscopy systems have recently emerged in portable and wearable form, there is much less work reported on the portable and wearable photoacoustic microscopy (PAM) systems. Working towards this goal, we report our studies on a low-cost and portable photoacoustic microscopy system that uses a custom fabricated 2.5 mm diameter ring ultrasound transducer integrated with a fiber-coupled laser diode. The ultrasound transducer is centered at 17.25 MHz, and shows similar to 45% and similar to 100% fractional bandwidths for ultrasound pulse-echo and photoacoustic A-line signals respectively. To achieve overall system portability, besides the imaging head, other back-end imaging system components need to be readily portable as well. In this direction, we have studied the potential use of compact pre-amplifiers, scanning stages and microcontroller-based data acquisition and reconstruction for photoacoustic imaging. The portable PAM system is validated by imaging phantoms embedded with light absorbing targets. Future directions that will likely help achieve a completely portable and wearable photoacoustic microscopy system are discussed.
机译：近年来使用先进的光声显微镜显微镜成像系统近年来据报道了生物医学成像的几种突破性应用。虽然最近以便携式和可穿戴形式出现的双光子和其他光学显微镜系统，但在便携式和可穿戴光声显微镜（PAM）系统上报告了更少的工作。努力实现这一目标，我们向我们的研究报告了对低成本和便携式光声显微镜系统的研究，该系统使用与光纤耦合激光二极管集成的定制制造的2.5 mm直径环超声换能器。超声换能器以17.25MHz为中心，并且分别显示出类似于45％且类似于超声波脉冲回波和光声A线信号的100％分数带宽。为了实现整体系统的便携性，除了成像头，其他后端成像系统的组件也需要容易地便携。在这种方向上，我们研究了紧凑的预放大器，扫描阶段和基于微控制器的数据采集和重建光声成像的潜在使用。通过嵌入光吸收目标的成像幻像验证便携式PAM系统。讨论了可能有助于实现完全便携和可穿戴光声学显微镜系统的未来方向。

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