Knocking Out Malaria?

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Knocking Out Malaria?

机译：消除疟疾？

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The world's first vaccines were made from weak forms of disease-causing microbes. A more modern approach is to instead use one or a few of a microbe's signature molecules. But the malariapara-site—Plasmodium—foils this strategy because at different developmental stages it has different surface proteins. However, the older approach also poses problems: insufficiently weakened parasites might bring on the disease, but overly weakened ones are ineffective.

机译：世界上第一种疫苗是由弱型致病微生物制成的。一种更现代的方法是改为使用一种或几种微生物的特征分子。但是，疟原虫位点-疟原虫-阻止了这种策略，因为在不同的发育阶段它具有不同的表面蛋白。但是，较旧的方法也带来了问题：弱化的寄生虫可能会导致疾病，而弱化的寄生虫则无效。

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《Technology Review》 |2005年第5期|p.8385|共2页
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正文语种 eng
中图分类工业技术;
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1. How far is the journey before malaria is knocked out of Zimbabwe? (or Africa): a commentary [J] . Clive Shiff Malaria Journal . 2019,第1期

机译：在疟疾被击倒津巴布韦之前旅程有多远？（或非洲）：评论
2. Conditional knock-out of lipoic acid protein ligase 1 reveals redundancy pathway for lipoic acid metabolism in Plasmodium berghei malaria parasite [J] . Min Wang, Qiong Wang, Xiang Gao, Parasites Vectors . 2017,第1期

机译：有条件地敲除硫辛酸蛋白连接酶1揭示了伯氏疟原虫疟原虫中硫辛酸代谢的冗余途径
3. Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key malaria vector in Latin America [J] . Juan C Lol, María E Castellanos, Kelly A Liebman, Parasites Vectors . 2013,第4期

机译：拉丁美洲主要的疟疾传播者albimanus按蚊的抗击倒性历史存在的分子证据
4. Some Insights on the Stochastic Nature of Knock and the Evolution of Hot Spots in the End-Gas During the Engine Cycle from Experimental Measurements of Knock Onset and Knock Intensity [C] . Gautam Kalghatgi, Kai Morganti, Ibrahim Algunaibet SAE International Powertrains, Fuels and Lubricants Meeting . 2017

机译：从爆震发作和敲击强度的实验测量中发动机循环过程中爆震随机性质的一些见解及最终气体的进化。
5. Biomarkers of severe malaria: Complement activation and dysregulated angiogenesis in placental malaria and cerebral malaria [D] . Conroy, Andrea 2011

机译：严重疟疾的生物标志物：胎盘疟疾和脑疟疾中的补体激活和血管生成失调
6. How far is the journey before malaria is knocked out malaria in Zimbabwe: results of the malaria indicator survey 2016 [O] . Busisani Dube, Joseph Mberikunashe, Patience Dhliwayo, 2019

机译：在津巴布韦消除疟疾之前要走多远：2016年疟疾指标调查的结果
7. Correction to: How far is the journey before malaria is knocked out in Zimbabwe: results of the malaria indicator survey 2016 [O] . Busisani Dube, Joseph Mberikunashe, Patience Dhliwayo, 2019

机译：纠正：在津巴布韦在津巴布韦淘汰疟疾前的旅程有多远：2016年疟疾指标调查结果

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