Selective solid phase extraction of propranolol on multiwell membrane filter plates modified with molecularly imprinted polymer

Tibor Renkecz Giorgio Ceolin and Viola Horváth

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Selective solid phase extraction of propranolol on multiwell membrane filter plates modified with molecularly imprinted polymer

机译：在分子印迹聚合物改性的多孔膜滤板上选择性固相萃取普萘洛尔

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Molecularly imprinted polymers (MIPs) were synthesized in 24-well glass fiber membrane filter platesnto obtain a novel type of solid phase extraction device for the cleanup of propranolol. Samplenprocessing parameters like residence time during sample loading, sample volume, pH, sample solvent,ntype and amount of washing and elution solvents were investigated and optimized. Importantndifferences from the traditional molecularly imprinted solid phase extraction (MISPE) cartridges havenbeen identified. The MIP modified composite membrane suits well for the sample preparation of lownvolume biological samples. A protocol has been elaborated for the quantitation of propranolol fromnurine and plasma samples in the clinically relevant concentration ranges. Preliminary validation resultsnindicate that the composite MIP membrane filter plates offer a viable alternative to existing MISPEncartridges and at the same time have advantages like much easier and faster synthesis method and highthroughputnanalysis.

机译：在24孔玻璃纤维膜滤板中合成了分子印迹聚合物（MIPs），从而获得了一种新型的固相萃取装置，用于普萘洛尔的净化。研究并优化了样品处理参数，例如样品加载期间的停留时间，样品体积，pH，样品溶剂，n类型以及洗涤和洗脱溶剂的量。尚未发现传统分子印迹固相萃取（MISPE）色谱柱的重要差异。 MIP改性的复合膜非常适合小批量生物样品的样品制备。已经制定了一种协议，用于从临床和相关浓度范围内的尿液和血浆样品中普萘洛尔进行定量。初步验证结果表明，复合MIP膜滤板可作为现有MISPEncartridges的可行替代品，同时具有诸如更简便，更快速的合成方法以及高通量分析的优势。

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《The Analyst》 |2011年第10期|p.2175-2182|共8页
作者
Tibor Renkecz Giorgio Ceolin and Viola Horváth;
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aDepartment of Inorganic and Analytical Chemistry, Budapest Universityof Technology and Economics, H-1111 Budapest, Szt. Gellu0001ert tu0001er 4.,HungarybResearch Group of Technical Analytical Chemistry, Hungarian Academyof Sciences-Budapest University of Technology and Economics, H-1111Budapest, Szt. Gellu0001ert tu0001er 4., Hungary. E-mail: vhorvath@mail.bme.hu;

Fax: +36 1 463 3408;

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1. Selective solid phase extraction of propranolol on multiwell membrane filter plates modified with molecularly imprinted polymer [J] . Renkecz T., Ceolin G., Horváth V. The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry . 2011,第10期

机译：在分子印迹聚合物改性的多孔膜滤板上选择性固相萃取普萘洛尔
2. In-Tube Molecularly Imprinted Polymer Solid-Phase Microextraction for the Selective Determination of Propranolol [J] . Wayne M. Mullett, Paul Martin, Janusz Pawliszyn Analytical chemistry . 2001,第11期

机译：管内分子印迹聚合物固相微萃取用于普萘洛尔的选择性测定
3. Predicting the performance of molecularly imprinted polymers: Selective extraction of caffeine by molecularly imprinted solid phase extraction [J] . Keith Farrington, Edmond Magner, Fiona Regan Analytica chimica acta . 2006,第1期

机译：预测分子印迹聚合物的性能：通过分子印迹固相萃取选择性萃取咖啡因
4. Selective Separation of Active Inhibitors of Epidermal Growth Factor Receptor from Caragana Jubata by Molecularly Imprinted Solid-phase Extraction [C] . 北京大学中医药现代研究中心2003年年会论文集 . 2004

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5. Development of polypyrrole encapsulated nanomaterials in a syringe needle for automated molecularly imprinted solid phase extraction of ochratoxin A. [D] . Wei, Yun. 2007

机译：开发用于自动分子印迹固相萃取encapsulate曲霉毒素A的注射器针头中聚吡咯包裹的纳米材料。
6. Combining Pickering Emulsion Polymerization with Molecular Imprinting to Prepare Polymer Microspheres for Selective Solid-Phase Extraction of Malachite Green [O] . Weixin Liang, Huawen Hu, Pengran Guo, 2017

机译：将Pickering乳液聚合与分子印迹相结合以制备用于选择性固相萃取孔雀石绿的聚合物微球
7. Solid-phase extraction using molecularly imprinted polymer for selective extraction of natural and syntetic estrogens from aqueous samples [O] . Lucci Paolo, Núñez Burcio Oscar, Galcerán Huguet M. Teresa 2016

机译：使用分子印迹聚合物固相萃取从水性样品中选择性萃取天然和合成雌激素

Selective solid phase extraction of propranolol on multiwell membrane filter plates modified with molecularly imprinted polymer

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