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Thrombotische Mikroangiopathien

机译：血栓形成

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摘要

Thrombotic microangiopathy should be suspected every time the combination of microangiopathic hemolytic anemia without a coexisting cause, thrombocytopenia as well as renal and/or neurologic abnormalities occurs. The general term thrombotic microangiopathy includes different subtypes of the disease leading to abnormalities in multiple organ systems by endothelial injury and formation of platelet-rich thrombi in small vessels. The main types include thrombotic thrombocytopenic purpura in case of dominant neurologic abnormalities and the hemolytic uremic syndrome in case of acute kidney injury, respectively. Although these syndromes differ in their etiologies, clinical features, response to treatment, and prognosis, an early initiation of a direct therapeutic intervention frequently determines the clinical course of the patient. Irrespectively of the underlying etiology, plasma exchange is an essential component of acute therapeutic intervention while ongoing diagnostics are used to identify the definite treatment.
机译：每次合并无共同原因的微血管性溶血性贫血，血小板减少症以及肾和/或神经系统异常时，都应怀疑血栓性微血管病。血栓性微血管病的总称包括该疾病的不同亚型，可通过内皮损伤导致多器官系统异常，并在小血管中形成富含血小板的血栓。主要类型分别包括在主要神经系统异常情况下的血栓性血小板减少性紫癜和在急性肾脏损伤情况下的溶血性尿毒症综合征。尽管这些综合征的病因，临床特征，对治疗的反应和预后各不相同，但直接开始进行直接的治疗干预常常决定了患者的临床病程。不管潜在的病因是什么，血浆交换是急性治疗干预的重要组成部分，而正在进行的诊断可用于确定明确的治疗方法。

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