Synthesis of Protected Tetrapeptide, N-o-Ns-N(Me)-Val-N(Me)-Val-N(Me)-Val-N(Me)-Phe-O~t Bu

CHEN Hongliang; FENG Yaqing; MENG Shuxian

首页> 外文期刊>Transactions of Tianjin University >Synthesis of Protected Tetrapeptide, N-o-Ns-N(Me)-Val-N(Me)-Val-N(Me)-Val-N(Me)-Phe-O~t Bu

【24h】

Synthesis of Protected Tetrapeptide, N-o-Ns-N(Me)-Val-N(Me)-Val-N(Me)-Val-N(Me)-Phe-O~t Bu

机译：保护性四肽N-o-Ns-N（Me）-Val-N（Me）-Val-N（Me）-Val-N（Me）-Phe-O〜t Bu的合成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The protected tetrapeptide, N-o-Ns-N (Me)-Val-N(Me)-Val-N(Me)-Val- N (Me)-Phe O~t Bu, was prepared from L-valine and L-phenylalanine. Tert-butyl acetate and HClO_4 were used to protect carbonyl group, o-nitrobenzenesulfonyl chloride and triethyl amine were used to protect ami-no group, and N-alkylation was finished with iodomethane. Then the protected amino acid was turned into acid chloride which was taken as coupling reagent. After 14 steps, such as protection, alkylation, deprotection and coupling, the protected tetrapeptide was obtained with a yield of 26.9 percent. The structures of intermediates and target compound were identified with NMR spectra and high resolution mass spectra.

机译：由L-缬氨酸和L-苯丙氨酸制备被保护的四肽No-Ns-N（Me）-Val-N（Me）-Val-N（Me）-Val-N（Me）-Phe Ot Bu。。用乙酸叔丁酯和HClO_4保护羰基，用邻硝基苯磺酰氯和三乙胺保护酰胺基，并用碘甲烷完成N-烷基化。然后将被保护的氨基酸转化为酰氯，将其用作偶联剂。经过保护，烷基化，脱保护和偶联等14个步骤后，获得了受保护的四肽，收率为26.9％。中间体和目标化合物的结构通过NMR光谱和高分辨率质谱鉴定。

著录项

来源
《Transactions of Tianjin University》 |2006年第5期|p.364-368|共5页
作者
CHEN Hongliang; FENG Yaqing; MENG Shuxian;
展开▼
作者单位

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
synthesis; tetrapeptide; L-valine; L-phenylalanine;

机译：合成;四肽;L-缬氨酸;L-苯丙氨酸;

相似文献

外文文献
中文文献
专利

1. Metal vapour synthesis of phospha-organometallic compounds via reaction of cobalt atoms with the phospha-alkyne (BuC)-Bu-t P: synthesis and structural characterisation of the sandwich compounds [Co(eta(5)-(P3C2Bu2)-Bu-t)(eta(4)-(P2C2Bu2)-Bu-t)], [Co [J] . Cloke FGN., Nixon JF., Vickers DM., Journal of Organometallic Chemistry . 2001,第1a2期

机译：通过钴原子与磷炔烃（BuC）-Bu-t反应的磷-有机金属化合物的金属蒸气合成：夹心化合物[Co（eta（5）-（P3C2Bu2）-Bu-t）的合成和结构表征）（eta（4）-（P2C2Bu2）-Bu-t）]，[Co
2. Orthogonally Protected Cyclo-β-tetrapeptides as Solid-Supported Scaffolds for the Synthesis of Glycoclusters [J] . Pasi Virta, Marika Karskela, Harri Loennberg The Journal of Organic Chemistry . 2006,第5期

机译：正交保护的环-β-四肽作为固体支撑的糖簇合成支架
3. Synthesis and Structural Analysis of Zr-Al Heterobimetallic Complexes, [ZrX{(O-2,4-(Bu2C6H2)-Bu-t-6-CH2)(3)(mu(2)-O-2,4-Bu-t(2)-C6H2-6-CH2)}N][R2Al(mu(2)-(OPr)-Pr-i)] [X = Cl, Et, Bu-i; R = Me, Et, Bu-i]. Unique Reactivity of the Bu-i Complex [J] . Tewasekson Udomchai, Tsutsumi Ken, Nomura Kotohiro Organometallics . 2016,第6期

机译：Zr-Al异双金属配合物[ZrX {（O-2,4-（Bu2C6H2）-Bu-t-6-CH2）（3）（mu（2）-O-2,4-Bu- t（2）-C6H2-6-CH2）} N] [R2Al（mu（2）-（OPr）-Pr-i）] [X = Cl，Et，Bu-i; R = Me，Et，Bu-i]。 Bu-i建筑群的独特反应性
4. Good Coupling Performance of PyBOP in the Solid-phase Synthesis of Tetrapeptide, OH-Pro-Leu-Ala-Ileu-NH_2 [C] . R. Maharani, N. Ammatillah, G. Muhammad, International Seminar on Mathematics, Science, and Computer Science Education . 2017

机译：在四肽的固相合成中Pybop的良好耦合性能，OH-Pro-Leu-Ala-Ileu-NH_2
5. I. Comparison of translesion bypass of guanine-N2 monoadducts of mitomycin C and guanine -N7 monoadducts of 2,7-diaminomitosene by T7 exo-, Klenow exo-, eta and Klenow exo+ DNA polymerases. II. Structure-based design, synthesis, structure-conformation and structure -activity relationships studies of D-Phe-Pro-D-Arg-P1'-CONH2 tetrapeptides with inhibitory activity for thrombin. [D] . Clement, Cristina C. 2006

机译：I.通过T7 exo-，Klenow exo-，eta和Klenow exo + DNA聚合酶比较丝裂霉素C的鸟嘌呤-N2单加合物和2,7-二氨基光油的鸟嘌呤-N7单加合物的跨病变旁路。二。具有凝血酶抑制活性的D-Phe-Pro-D-Arg-P1'-CONH2四肽的基于结构的设计，合成，结构构象和结构-活性关系研究。
6. Synthesis and NMR-Study of 1-Trimethylsilyl Substituted Silole Anion Ph4C4Si(SiMe3)−•Li+ and 3-Silolenide 25-carbodianions {Ph4C4Si(n-Bu)2−2•2Li+ Ph4C4Si(t-Bu)2−2•2Li+} via Silole Dianion Ph4C4Si−2•2Li+ [O] . Jang-Hwan Hong 2013

机译：1-三甲基甲硅烷基取代的硅烷阴离子Ph4C4Si（SiMe3）-•Li +和3-硅氧烷亚胺25-碳二阴离子{Ph4C4Si（n-Bu）2 -2•2 Li的合成及NMR研究+Ph4C4Si（t-Bu）2 −2•2 Li +}通过Silole Dianion Ph4C4Si −2•2 Li +
7. Orthogonally Protected Cyclo-b-tetrapeptides as Solid-Supported Scaffolds for the Synthesis of Glycoclusters [O] . -1

机译：正交保护的环-b-四肽作为用于合成糖蛋白的固体支持的支架
8. Synthesis and Characterization of Tert-Butylgallium-Antimony Compounds; X-RayCrystal Structures of t-Bu3GaSb(SiMe3)3, t-Bu2GaSb(SiMe3)2, and t-Bu2GaSb(SiMe3)Ga(t-Bu)2Cl, The First Example of a Gallium-Antimony Mixed-Bridge Compound [R] . Wells, R. L., Foos, E. E., White, P. S., 1997

机译：叔丁基镓 - 锑化合物的合成与表征; t-Bu3Gasb（sime3）3，t-Bu2Gasb（sime3）2和t-Bu2Gasb（sime3）Ga（t-Bu）2Cl的X射线晶体结构，镓 - 锑混合桥化合物的第一个例子

Synthesis of Protected Tetrapeptide, N-o-Ns-N(Me)-Val-N(Me)-Val-N(Me)-Val-N(Me)-Phe-O~t Bu

摘要

著录项

相似文献

相关主题

期刊订阅