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首页> 外文期刊>Translational Stroke Research >The Effects of Estrogen in Ischemic Stroke
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The Effects of Estrogen in Ischemic Stroke

机译：雌激素在缺血性卒中中的作用

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摘要

Stroke is a leading cause of death and the most common cause of long-term disability in the USA. Women have a lower incidence of stroke compared with men throughout most of the lifespan which has been ascribed to protective effects of gonadal steroids, most notably estrogen. Due to the lower stroke incidence observed in pre-menopausal women and robust preclinical evidence of neuroprotective and anti-inflammatory properties of estrogen, researchers have focused on the potential benefits of hormones to reduce ischemic brain injury. However, as women age, they are disproportionately affected by stroke, coincident with the loss of estrogen with menopause. The risk of stroke in elderly women exceeds that of men and it is clear that in some settings estrogen can have pro-inflammatory effects. This review will focus on estrogen and inflammation and its interaction with aging.
机译：中风是导致死亡的主要原因，也是美国长期残疾的最常见原因。与男性相比，女性在整个生命周期中的中风发生率均较低，这归因于性腺类固醇，尤其是雌激素的保护作用。由于绝经前妇女中风的发生率较低，并且有充分的临床前证据表明雌激素具有神经保护和抗炎特性，因此研究人员集中研究了激素在减少缺血性脑损伤方面的潜在益处。但是，随着女性年龄的增长，她们更容易受到中风的影响，并伴随着绝经期雌激素的流失。老年妇女中风的风险超过男性，很明显，在某些情况下，雌激素可能具有促炎作用。这篇综述将集中在雌激素和炎症及其与衰老的相互作用上。

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