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首页> 外文期刊>Translational Stroke Research >Sampling of CSF via the Cisterna Magna and Blood Collection via the Heart Affects Brain Water Content in a Rat SAH Model
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Sampling of CSF via the Cisterna Magna and Blood Collection via the Heart Affects Brain Water Content in a Rat SAH Model

机译：通过水罐大麦取样脑脊液和通过心脏采血影响大鼠SAH模型的脑含水量

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摘要

The aim of this study was to evaluate whether sampling of cerebrospinal fluid (CSF) via the cisterna magna and of blood via the heart affects brain water content in a rat subarachnoid hemorrhage (SAH) model. Twenty-nine animals were divided into four groups: sham-operated group with sampling of CSF and blood (Sham S+), sham-operated group without sampling of CSF and blood (Sham S?), SAH group with sampling of CSF and blood (SAH S+), and SAH without sampling of CSF and blood (SAH S?). SAH was induced via endovascular perforation of the left internal carotid artery bifurcation. Cerebrospinal fluid via the cisterna magna and blood via cardiac puncture was collected in the Sham S+ and SAH S+ groups before killing the animals for brain water content measurements. Left hemisphere brain water content was significantly higher in the SAH S? group compared with the Sham S? group (p < 0.05) and in Sham S+ group compared with the Sham S? group (p < 0.05). There was no significant difference in brain water content of the left hemisphere between the SAH S+ and Sham S+ groups (p = NS). There was no significant difference in brain water content in other parts of brains. Sampling of CSF and blood affected brain water content in Sham animals and therefore it is not accurate to use these values from Sham animals for comparison with SAH animals.
机译：这项研究的目的是评估通过大水罐采集的脑脊液（CSF）和通过心脏采集的血液是否会影响大鼠蛛网膜下腔出血（SAH）模型中的脑含水量。将29只动物分为四组：假手术组，采集CSF和血液（Sham S +）；假手术组，不采集CSF和血液（Sham S？）； SAH组，采集CSF和血液（Sham）。 SAH S +）和SAH，而无需采集CSF和血液（SAH S？）。 SAH是通过左颈内动脉分叉的血管内穿孔诱导的。在杀死动物以测量脑含水量之前，在Sham S +和SAH S +组中收集通过大水罐的脑脊液和通过心脏穿刺的血液。 SAH S？中左半球的大脑含水量明显更高？组与深水S相比？组（p <0.05），而Sham S +组与Sham S？组相比？组（p ＜0.05）。 SAH S +组和Sham S +组之间左半球的脑含水量无显着差异（p = NS）。大脑其他部位的大脑含水量没有显着差异。 CSF和血液的采样会影响Sham动物的脑含水量，因此将Sham动物的这些值与SAH动物进行比较并不准确。

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  • 来源
    《Translational Stroke Research》 |2011年第2期|232-237|共6页
  • 作者

    Kamil Duris; Anatol Manaenko; Hidenori Suzuki; William Rolland; Jiping Tang; John H. Zhang;

  • 作者单位

    Department of Physiology and Pharmacology Loma Linda University School of Medicine Loma Linda CA USA;

    Department of Physiology and Pharmacology Loma Linda University School of Medicine Loma Linda CA USA;

    Department of Physiology and Pharmacology Loma Linda University School of Medicine Loma Linda CA USA;

    Department of Physiology and Pharmacology Loma Linda University School of Medicine Loma Linda CA USA;

    Department of Physiology and Pharmacology Loma Linda University School of Medicine Loma Linda CA USA;

    Department of Physiology and Pharmacology Loma Linda University School of Medicine Loma Linda CA USA;

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  • 正文语种 eng
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  • 关键词

    SAH; Rat; Brain water content; Blood; CSF;

    机译：SAH;大鼠;脑含水量;血液;CSF;

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