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首页> 外文期刊>Translational Stroke Research >Hyperbaric Oxygen for Cerebral Vasospasm and Brain Injury Following Subarachnoid Hemorrhage
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Hyperbaric Oxygen for Cerebral Vasospasm and Brain Injury Following Subarachnoid Hemorrhage

机译：高压氧治疗蛛网膜下腔出血后脑血管痉挛和脑损伤

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摘要

The impact of acute brain injury and delayed neurological deficits due to cerebral vasospasm (CVS) are major determinants of outcomes after subarachnoid hemorrhage (SAH). Although hyperbaric oxygen (HBO) had been used to treat patients with SAH, the supporting evidence and underlying mechanisms have not been systematically reviewed. In the present paper, the overview of studies of HBO for cerebral vasospasm is followed by a discussion of HBO molecular mechanisms involved in the protection against SAH-induced brain injury and even, as hypothesized, in attenuating vascular spasm alone. Faced with the paucity of information as to what degree HBO is capable of antagonizing vasospasm after SAH, the authors postulate that the major beneficial effects of HBO in SAH include a reduction of acute brain injury and combating brain damage caused by CVS. Consequently, authors reviewed the effects of HBO on SAH-induced hypoxic signaling and other mechanisms of neurovascular injury. Moreover, authors hypothesize that HBO administered after SAH may “precondition” the brain against the detrimental sequelae of vasospasm. In conclusion, the existing evidence speaks in favor of administering HBO in both acute and delayed phase after SAH; however, further studies are needed to understand the underlying mechanisms and to establish the optimal regimen of treatment.
机译：急性脑损伤的影响和由于脑血管痉挛（CVS）引起的延迟神经功能缺损是蛛网膜下腔出血（SAH）后结局的主要决定因素。尽管高压氧（HBO）已用于治疗SAH患者，但尚未系统地评估支持证据和潜在机制。在本文中，对HBO治疗脑血管痉挛的研究进行了概述，随后讨论了HBO分子机制，参与了针对SAH诱导的脑损伤的保护，甚至可以假设单独抑制血管痉挛。面对缺乏足够程度的HBO能够对抗SAH后血管痉挛的信息，作者推测HBO在SAH中的主要有益作用包括减少急性脑损伤和对抗CVS引起的脑损伤。因此，作者回顾了HBO对SAH诱导的缺氧信号传导和其他神经血管损伤机制的影响。此外，作者假设在SAH后服用HBO可能“使”大脑对抗血管痉挛的有害后遗症。总而言之，现有证据支持在SAH后的急性期和延迟期使用HBO。然而，需要进一步的研究以了解其潜在机制并建立最佳治疗方案。

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