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Acaricidal efficacy against cattle ticks and acute oral toxicity of Lippia javanica (Burm F.) Spreng

机译:牛tick的杀螨功效和爪哇小pp(Burm F.)Spreng的急性口服毒性

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摘要

In search for low-cost, safe and environmentally benign plant-based alternatives to commercial pesticides, the efficacy of Lippia javanica aqueous leaf extracts in controlling ticks on cattle, acute oral toxicity in mice and phytochemistry were evaluated. L. javanica aqueous leaf extracts at 10% and 20% w/v were effective at controlling cattle ticks but not as good as an amitraz-based acaricide Tickbuster®. However, they can provide an effective tick control option where synthetic products are unavailable or unaffordable, particularly in remote parts of southern Africa. Peripheral blood samples collected showed no haemoparasites in treated cattle implying that animals did not suffer from clinical tick-borne diseases. The leaf aqueous extracts of L. javanica were tested for toxicity in BALB/c mice. While anecdotal evidence suggests L. javanica has low mammalian toxicity, within 48 h all mice fed with the L. javanica leaf aqueous extract at 12.5–37.5% v/v were lethargic, and overall mortality was 37.5% (n = 24). Thus, despite their apparent safety, water extracts of L. javanica leaves may have deleterious health implications on humans and animals if consumed at very high doses. Many compounds have been identified from L. javanica including an array of phenolic glycosides, flavonoids and essential oils but none of these are known to have acute toxic properties.
机译:在寻找低成本,安全和环境友好的植物性商业农药替代品时,对爪哇Lippia含水叶提取物控制牛tick,小鼠急性口服毒性和植物化学的功效进行了评估。 L. javanica叶片含水量为10%和20%w / v的提取物在控制牛tick上有效,但不如基于阿米特拉斯的杀螨剂Tickbuster®。但是,在合成产品无法获得或无法承受的地方,尤其是在南部非洲的偏远地区,它们可以提供有效的tick控制选项。收集的外周血样本显示,经过治疗的牛没有血寄生虫,这表明动物没有患上由tick传播的临床疾病。测试了爪哇L.javanica的叶水提物对BALB / c小鼠的毒性。尽管有传闻证据表明爪哇紫花苜蓿对哺乳动物的毒性较低,但在48小时内,所有饲喂爪哇紫苏叶水提取物的12.5-37.5%v / v小鼠均嗜睡,总死亡率为37.5%(n = 24)。因此,尽管爪蟾叶的水提取物具有明显的安全性,但如果以非常高的剂量食用,则可能对人类和动物的健康造成不利影响。已经从爪哇乳酸杆菌中鉴定出许多化合物,包括一系列酚糖苷,类黄酮和精油,但已知这些化合物都不具有急性毒性。

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