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首页> 外文期刊>Tropical Animal Health and Production >Putative probiotic Lactobacillus spp. from porcine gastrointestinal tract inhibit transmissible gastroenteritis coronavirus and enteric bacterial pathogens
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Putative probiotic Lactobacillus spp. from porcine gastrointestinal tract inhibit transmissible gastroenteritis coronavirus and enteric bacterial pathogens

机译：推定的益生菌乳杆菌属。来自猪胃肠道的抑制性传染性胃肠炎冠状病毒和肠细菌病原体

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摘要

A total of 310 bacterial strains isolated from the porcine gastrointestinal tract were tested for their activity against transmissible gastroenteritis (TGE) coronavirus and other enteric pathogens. Based on activity, the strains Probio-38 and Probio-37 were selected as potential probiotics and identified as Lactobacillus plantarum Probio-38 and Lactobacillus salivarius Probio-37 respectively by 16S rRNA gene sequencing. Supernatants of these strains inhibited TGE coronavirus in vitro in ST cells, without any cytopathic effect even after 72 h of incubation. Both the strains exhibited high survival in synthetic gastric juice. The strains were resistant to 5% porcine bile and exhibited antimicrobial activity against all the 13 enteric bacterial pathogens tested. These strains also exhibited resistance to most of the antibiotics analyzed. The inhibition of transmissible gastroenteritis coronavirus and enteric bacterial pathogens as well as the bile tolerance, high survival in gastric juice, and the antibiotic resistance indicate that the two isolated bacterial strains are ideal probiotic candidates for animal application after proper in vivo experiments.
机译：测试了从猪胃肠道分离出的总共310种细菌菌株对传染性胃肠炎（TGE）冠状病毒和其他肠道病原体的活性。根据活性，通过16S rRNA基因测序将菌株Probio-38和Probio-37选为潜在的益生菌，并分别鉴定为植物乳杆菌Probio-38和唾液乳杆菌Probio-37。这些菌株的上清液在体外在ST细胞中抑制TGE冠状病毒，即使在孵育72小时后也没有任何细胞病变作用。两种菌株在合成胃液中均显示出高存活率。该菌株对5％的猪胆汁有抗性，并且对测试的所有13种肠细菌病原体均表现出抗菌活性。这些菌株还显示出对大多数分析抗生素的抗性。传播性胃肠炎冠状病毒和肠细菌病原体的抑制以及胆汁耐受性，胃液中的高存活率和抗生素抗性表明，经过适当的体内实验后，这两种分离的细菌菌株是理想的动物益生菌候选物。

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