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Comparative susceptibility of indigenous and improved pig breeds to Classical swine fever virus infection: Practical and epidemiological implications in a subsistence-based, developing country setting

机译:本地和改良猪品种对经典猪瘟病毒感染的比较易感性:在以生计为基础的发展中国家中的实际和流行病学意义

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摘要

This study investigated the comparative susceptibility of indigenous Moo Laat and improved Large White/Landrace pig breeds to infection with classical swine fever virus (CSFV) under controlled conditions in the Lao People’s Democratic Republic (Lao PDR). The Moo Laat (ML) and Large White/Landrace crossbreed (LWC) pigs were inoculated with a standard challenge strain designated Lao/Kham225 (infectivity titre of 102.75 TCID50/ml). The results demonstrated that both the native breed and an improved pig breed are fully susceptible to CSFV infection and the mortality rate is high. LWC pigs demonstrated lower (or shorter) survival times (50% survival time: 11 days), earlier and higher pyrexia and earlier onset of viraemia compared to ML pigs (50% survival time: 18 days). In the context of village-based pig production, the longer time from infection to death in native ML pigs means that incubating or early sick pigs are likely to be sold once an outbreak of CSF is recognized in a village. This increased longevity probably contributes to the maintenance and spread of disease in a population where generally the contact rate is low.
机译:这项研究调查了老挝人民民主共和国(Lao PDR)在受控条件下,原产Moo Laat和改良的大型白色/长白猪品种对经典猪瘟病毒(CSFV)感染的敏感性。将Moo Laat(ML)和大型白色/长系杂交(LWC)猪接种称为Lao / Kham225的标准攻击株(感染力滴度TCID50 / ml)。结果表明,无论是本地品种还是改良猪品种都完全容易感染猪瘟病毒,死亡率很高。与ML猪(50%的生存时间:18天)相比,LWC猪的生存时间更短(或更短)(50%生存时间:11天),发热更高,发热更高,病毒血症发作更早。在以乡村为基础的养猪生产中,本地ML猪从感染到死亡的时间更长,这意味着一旦在一个村庄中认识到脑脊液爆发,就可能出售孵化期或生病的早期猪。这种延长的寿命可能有助于疾病的维持和传播,而这些人群的接触率通常较低。

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