Structural-conformational factors of recognition of benzodiazepine ligands by benzodiazepine receptors

Andronati S.A.; Makan S.Y.

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Structural-conformational factors of recognition of benzodiazepine ligands by benzodiazepine receptors

机译：苯并二氮杂receptor受体识别苯并二氮杂ligand配体的结构构象因素

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Recognition of ligands by benzodiazepine receptors and the following biological response are dealt with the conformation states of a-subunit of GABAA-Channel (GABA_A-receptor), as well as with structural and conformation characteristics of ligands. Established appropriateness of binding between structure-conformation ligands characteristics and their affinity for benzodiazepine receptors are used in modelling of the ligand-receptor interaction process and in directed synthesis of psychotropic substances with the required complex of properties.

机译：苯并二氮杂receptor受体对配体的识别和以下生物学反应涉及GABAA通道a亚基的构象状态（GABA_A受体），以及配体的结构和构象特征。建立的结构构型配体特征之间的结合及其对苯并二氮杂receptor受体的亲和力的适当性被用于配体-受体相互作用过程的模型化以及具有所需性质复杂性的精神药物的定向合成中。

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《Украинский химический журнал》 |1999年第10期|p.5-16|共12页
作者
Andronati S.A.; Makan S.Y.;
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收录信息美国《科学引文索引》(SCI);
原文格式 PDF
正文语种 rus
中图分类化学;
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1. Fluorescent-labeled ligands for the benzodiazepine receptor. Part 2: The choice of an optimal fluorescent-labeled ligand for benzodiazepine receptor assays. [J] . Janssen MJ, Ensing K, de Zeeuw-RA Die Pharmazie . 2000,第2期

机译：苯并二氮杂receptor受体的荧光标记配体。第2部分：苯并二氮杂receptor受体测定的最佳荧光标记配体的选择。
2. Determinants of recognition of ligands binding to benzodiazepine receptor/GABA(A) receptors initiating sedation. [J] . Harris DL, DeLorey TM, He X, European Journal of Pharmacology: An International Journal . 2000,第3期

机译：识别与苯并二氮杂receptor受体/ GABA（A）受体结合的配体的参考决定因素，以启动镇静作用。
3. GABA(A)/central benzodiazepine receptor and peripheral benzodiazepine receptor ligands as inducers of phenobarbital-inducible CYP2B and CYP3A. [J] . Roberge C, Beaudet MJ, Anderson A Biochemical Pharmacology . 2004,第7期

机译：GABA（A）/中央苯并二氮杂receptor受体和外围苯并二氮杂receptor受体配体作为苯巴比妥诱导的CYP2B和CYP3A的诱导剂。
4. Peripheral benzodiazepine receptor ligand-PLGA polymer conjugates potentially useful asdelivery systems of apoptoticeuroactive agents [C] . V. Laquintana, N. Denora, A. Latrofa, Annual meeting exposition of the Controlled Release Society . 2009

机译：外周苯并二氮杂receptor受体配体-PLGA聚合物共轭物可能对凋亡/神经活性剂的递送系统有用
5. Part I. Unified pharmacophore protein models of the benzodiazepine receptor subtypes. Part II. Subtype selective ligands for α5 Gaba(A) /BZ receptors [D] . Clayton, Terrill S. 2011

机译：第一部分。苯并二氮杂receptor受体亚型的统一药效团蛋白模型。第二部分亚型α5Gaba（A）/ BZ受体的选择性配体
6. Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABAA Receptor [O] . Yasushi Yabuki, Jiaqi Liu, Ichiro Kawahata, 2020

机译：Fabp3配体Mf1通过GABAA受体苯二氮卓识别部位的抗癫痫作用
7. Characteristics of the Association of Brotizolam, a Thieno-Triazolo Diazepine Derivative, with the Benzodiazepine Receptor: A Selective and High Affinity Ligand of the Central Type I Benzodiazepine Receptor. [O] . Masaaki Hirouchi, Hiroshi Mizutani, Yasuko Kohno, 1992

机译：Brotizolam，Thieno-Trizoolo二氮杂猪衍生物的特征，具有苯并二氮杂卓受体：中枢型I苯并二氮卓受体的选择性和高亲和力配体。

Structural-conformational factors of recognition of benzodiazepine ligands by benzodiazepine receptors

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