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Outcome of surgical treatment of colorectal cancer in the elderly

机译：老年人结直肠癌的外科治疗结果

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摘要

The aim of this study is to compare the clinical features and the perioperative and long-term outcomes after primary surgery for colorectal cancer (CRC) in the elderly population with those observed in younger patients. All the patients over the age of 55 who underwent primary surgery for CRC in our clinic from 1988 to 2008 were included in this study and divided into two age groups: 55–75 and >75 years considering the age of diagnosis. 914 consecutive patients were enrolled in the study (352 > 75 years). In the elderly group, tumors were predominantly right sided, and the overall number of comorbidities was statistical more frequent. Elderly patients underwent emergency surgery more than the control group (p = 0.0008). There were no significant differences between the two groups in terms of curative and palliative resections. The overall operative mortality rate was 5.9% in the study group compared with 2.1% in the control study (p = 0.0033). The overall 3-year, 5-year and 10-year survival rates were, respectively, 37, 16.2 and 5.1% in the study group, when compared with 52.3, 35.1 and 24.7% in the control group (p = 0.022, p = 0.0001 and p = 0.0001, respectively). More patients were lost during the follow-up in the elderly group (p = 0.0003) and more deaths unrelated to cancer were found in the study group compared with the control group (p = 0.0005). The cancer specific mortality was similar between the two groups. In conclusion, elderly patients that underwent major colorectal resection have an acceptable perioperative morbidity, mortality and survival rate when compared with younger patients. Age alone should not be considered a reason to deny surgery to these patients.
机译：这项研究的目的是比较老年人群与年轻患者所观察到的结直肠癌（CRC）的临床特征以及围手术期和长期结局。 1988年至2008年在我们诊所中接受CRC初次手术的所有55岁以上患者均纳入本研究，并考虑诊断年龄分为两个年龄段：55-75岁和> 75岁。连续914名患者参加了研究（352> 75岁）。在老年组中，肿瘤主要在右侧，并且合并症的总数在统计上更为频繁。老年患者比对照组接受了更多的急诊手术（p = 0.0008）。两组在根治性和姑息性切除方面无显着差异。研究组的总手术死亡率为5.9％，而对照组为2.1％（p = 0.0033）。研究组的3年，5年和10年总生存率分别为37％，16.2％和5.1％，而对照组为52.3％，35.1％和24.7％（p = 0.022，p = 0.0001和p = 0.0001）。与对照组相比，老年组中随访期间失访的病人更多（p = 0.0003），与癌症无关的死亡人数也更多（p = 0.0005）。两组之间的癌症特异性死亡率相似。总之，与年轻患者相比，接受大肠切除术的老年患者围手术期发病率，死亡率和存活率均可接受。仅年龄不应该被视为拒绝对这些患者进行手术的原因。

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  • 来源
    《Updates in Surgery》 |2011年第4期|233-237|共5页
  • 作者

    Andrea Fontani; Jacopo Martellucci; Serenella Civitelli; Gabriello Tanzini;

  • 作者单位

    General Surgery I University of Siena Ospedale Le Scotte Viale Bracci 53100 Siena Italy;

    General Surgery I University of Siena Ospedale Le Scotte Viale Bracci 53100 Siena Italy;

    General Surgery I University of Siena Ospedale Le Scotte Viale Bracci 53100 Siena Italy;

    General Surgery I University of Siena Ospedale Le Scotte Viale Bracci 53100 Siena Italy;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Elderly; Colorectal cancer; Surgery; Outcome;

    机译：老年人;大肠癌;外科手术;结果;

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