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首页> 外文期刊>Microbiology >The Induction in a Saccharomyces sp. of the Gene-mutation controlling Utilization of Galactose by Exposure. to Galactose
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The Induction in a Saccharomyces sp. of the Gene-mutation controlling Utilization of Galactose by Exposure. to Galactose

机译：Saccharomyces sp中的诱导。通过暴露的半乳糖基因突变控制利用。到半乳糖

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SUMMARY: The Carbondale yeast stock contains cultures which are characterized by the delayed fermentation of galactose. Long-term adaptation to galactose results from gene-mutation followed by the selection of the mutant in the presence of galactose. The original non-fermenter and the derived fermenter mutant contain no galactozymase and possess no selective advantage over each other when grown in glucose. Three different methods (variance analysis, fluctuation-redistribution tests, and chemostat experiments) which have been used with success in the detection of spontaneous mutations showed that the mutation to ability to ferment galactose did not occur spontaneously in these stocks. Exposure of non-dividing non-fermenter cells of the long-term fermenter to galactose induced the mutation to the fermenter type in a small but relatively constant number of cells, while exposure to glucose, ribose or lactose was ineffective; dividing cells were not susceptible to themutagenic action of galactose. Prolonging the exposure of the cells on galactose agar plates increased the number of mutations. It is inferred that the induction of the mutationresults from the impingement of galactose on the gene-surface thus modelling the gene-surf'ace into a mirror-image of the substrate.
机译：摘要：Carbondale酵母库存含有培养物，其特征在于半乳糖的延迟发酵。长期适应半乳糖由基因突变产生，然后在半乳糖存在下选择突变体。原始的非发酵罐和衍生的发酵蛋白突变体含有吡酰酸酯，并且在葡萄糖中生长时彼此不具有选择性优势。在自发突变检测中已经使用的三种不同的方法（方差分析，波动试验和化学稳定实验）表明，在这些储备中不会自发地发生发酵半乳糖的能力。将长期发酵罐的非分割非发酵罐细胞暴露于半乳糖诱导在小但相对恒定数量的细胞中对发酵罐类型的突变，同时暴露于葡萄糖，核糖或乳糖是无效的;分裂细胞不易受半乳糖的题级作用的影响。延长细胞暴露在半乳糖琼脂平板上增加突变的数量。推断，从基因表面的基因表面撞击半乳糖的诱导将基因冲浪的表面建模到基材的镜像上。

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