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首页> 外文期刊>Journal of Virology >Growth of Pseudotypes of Vesicular Stomatitis Virus with N-Tropic Murine Leukemia Virus Coats in Cells Resistant to N-Tropic Viruses
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Growth of Pseudotypes of Vesicular Stomatitis Virus with N-Tropic Murine Leukemia Virus Coats in Cells Resistant to N-Tropic Viruses

机译:用N-Tropic鼠白血病病毒涂层对N-热带病毒的细胞生长囊肿病毒的生长

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Formation of pseudotypes between murine RNA tumor viruses and vesicular stomatitis virus (VSV) has been confirmed. Pseudotypes of VSV genomes coated by the surface envelope from an N-tropic tumor virus grew equally well in cells homozygous for either the Fv-1n or Fv-1b alleles. Therefore, the product of the Fv-1 locus, which restricts growth of murine RNA tumor viruses, must act on an intracellular aspect of tumor virus replication, a step after attachment and penetration.
机译:已经证实了鼠RNA肿瘤病毒和脉络膜炎病毒(VSV)之间的伪型的形成。来自N-热带肿瘤病毒的表面封套涂覆的VSV基因组的假型在纯合的细胞中同样良好地增长,用于纯合的 FV-1 N FV-1 b 等位基因。因此,限制鼠RNA肿瘤病毒的生长的 Fv-1 基因座的产物必须对肿瘤病毒复制的细胞内方面作用,附着和渗透后的步骤。

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