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Cephalosporinase and Penicillinase Activity of Gram-negative Bacteria

机译：革兰氏阴性细菌的头孢菌素酶和青霉素酶活性

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SUMMARY: Sensitivity to ampicillin and cephalothin, the formation and induction of penicillinase and cephalosporinase, and the role of cephalosporinase in resistance to cephalothin were investigated in nine strains of Gramnegative bacteria. Naturally occurring strains resistant to cephalothin formed cephalosporinase, and ampicillin-resistant strains formed penicillinase. Cephalothin-resistant strains were all resistant to ampicillin, but the ampicillin-resistant strain of Proteus mirabilis was sensitive to cephalothin and did not form cephalosporinase. Penicillinase and cephalosporinase activity were induced by benzylpenicillin in five strains of Gram-negative bacteria and cephalosporinase was also induced by cephalothin and 6-amino-penicillanic acid in four of the inducible strains examined. Methicillin and quinacillin were variable in effect as inducers and cloxacillin partially inhibited cephalosporinase activity of two strains. Intrinsic resistance to cephalothin was high in four of five naturally occurring resistant strains.
机译：概述：对氨苄青霉素和头孢菌素的敏感性，青霉素酶和头孢菌素蛋白酶的形成和诱导，以及九株革兰氏结菌的含氮血管孢子蛋白酶对头孢菌素的作用。天然存在于头孢菌素形成头孢菌素蛋白酶的抗性菌株，并且氨苄青霉素抗性菌株形成青霉素酶。抗头脑抗性菌株耐药于氨苄青霉素，但蛋白质抗蛋白酶抗性菌株对头孢氨苄敏感，并未形成头孢菌素蛋白酶。通过苄基培素诱导青霉素酶和头孢菌素酶活性，在五种革兰氏阴性细菌中，Cephalothin和6-氨基 - 青霉酸在四个诱导诱导菌株中也诱导头孢菌素酶。 Methicililin和喹匹林蛋白的变化有效，因为诱导剂和克罗克林部分抑制了两个菌株的头孢菌素酶活性。五种天然存在的抗性菌株中的四种中有四种耐受性抗性素的固有抗性。

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    《Microbiology》 |1965年第1期|共8页
  • 作者

    G. A. J. AYLIFFE;

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  • 收录信息 美国《科学引文索引》(SCI);
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