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首页> 外文期刊>Journal of Virology >Deoxyribonucleic Acid Replication in Simian Virus 40-Infected Cells III. Comparison of Simian Virus 40 Lytic Infection in Three Different Monkey Kidney Cell Lines
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Deoxyribonucleic Acid Replication in Simian Virus 40-Infected Cells III. Comparison of Simian Virus 40 Lytic Infection in Three Different Monkey Kidney Cell Lines

机译：亚麻病毒40感染细胞III中的脱氧核糖核酸复制。三种不同猴子肾细胞系中猿猴病毒40裂变感染的比较

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摘要

A comparative study of simian virus 40 (SV40) lytic infection in three different monkey cell lines is described. The results demonstrate that viral deoxyribonucleic acid (DNA) synthesis and infectious virus production begin some 10 to 20 hr earlier in CV-1 cells and primary African green monkey kidney (AGMK) cells than in BSC-1 cells. Induction of cellular DNA synthesis by SV40 was observed in CV-1 and AGMK cells but not with BSC-1 cells. Excision of large molecular weight cellular DNA to smaller fragments was easily detectable late in infection of AGMK cells. Little or no excision was observed at comparable times after infection of CV-1 and BSC-1 cells. The different kinds of responses of these three monkey cell lines during SV40 lytic infection suggest the involvement of cellular functions in the virus-directed induction of cellular DNA synthesis and the excision of this DNA from the genome.
机译：描述了三种不同猴细胞系中猿猴病毒40（SV40）裂解感染的对比研究。结果表明，病毒脱氧核糖核酸（DNA）合成和传染病病毒产量在CV-1细胞和原发性非洲绿猴肾（AGMK）细胞中以比BSC-1细胞提前约10至20小时。在CV-1和AgMK细胞中观察到SV40的细胞DNA合成的诱导，但不具有BSC-1细胞。在AGMK细胞感染后，容易检测到大分子量细胞DNA的大分子量细胞DNA。在感染CV-1和BSC-1细胞后，在可比时段观察到很少或没有切除。在SV40裂解感染期间，这三种猴细胞系的不同类型的反应表明细胞功能在病毒定向诱导细胞DNA合成和来自基因组的切除中的累积。

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