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首页> 外文期刊>Infection and immunity >Depressed specific cell-mediated immunity to Herpes simplex virus type 1 in patients with recurrent herpes labialis.
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Depressed specific cell-mediated immunity to Herpes simplex virus type 1 in patients with recurrent herpes labialis.

机译：抑制特异性细胞介导的患有复发性疱疹性疱疹患者的单纯疱疹病毒患者的免疫力。

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摘要

Cell-mediated immunity to herpes simplex virus type 1 (HSV-1) was assessed by a lymphocytotoxicity 51-Cr-release microassay procedure, using the MA-160 human prostatic adenoma cell line chronically infected with HSV-1 and its parent cell line as control. The specific immune release mean plus or minus standard deviation for nine asymptomatic patients with recurrent HSV-1 infections was 13.7 plus or minus 8.1%, compared to 28.9 plus or minus 8.4% in seven normal seropositive controls (P is less than 0.01). In four additional patients studied serially, the cell-mediated immunity was significantly increased during the recrudescence of herpetic infection, with a mean specific immune release value of 51.7 plus or minus 27.8%, compared to 8.7 plus or minus 1.5% during the convalescent period 2 to 10 weeks later (P is less than 0.05). These findings suggest that patients with recurrent HSV-1 infections have vigorous cellular immune responses during the acute phase but a specific impairment of cell-mediated immunity during the quiescent period, which may in part account for their susceptibility to recurrent herpetic infections.
机译：通过淋巴细胞毒性51-CR释放微asseAly评估细胞介导的单纯疱疹病毒类型1（HSV-1），使用慢性感染HSV-1及其亲本细胞系的MA-160人前列腺腺瘤细胞系评估控制。九个无症状患者的特异性免疫释放平均值加入或负标准偏差为七个正常的HSV-1感染患者的患者为13.7次或减少8.1％，而七个正常血清阳性对照中的28.9加号或减去8.4％（P小于0.01）。在四种额外的患者中，在串联研究的患者中，在注重患者感染的倒退期间，细胞介导的免疫显着增加，其平均特异性免疫释放值51.7加或减去27.8％，而康复期间的8.7加号为1.5％到10周后（P小于0.05）。这些研究结果表明，患有复发性HSV-1感染的患者在急性期内具有剧烈的细胞免疫应答，但在静态期间细胞介导的免疫的特定损害，部分占他们对复发性患者感染的敏感性。

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