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首页> 外文期刊>Infection and immunity >T lymphocyte function as the principal target of lymphocytic choriomeningitis virus-induced immunosuppression.
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T lymphocyte function as the principal target of lymphocytic choriomeningitis virus-induced immunosuppression.

机译：T淋巴细胞功能作为淋巴细胞核心炎病毒诱导的免疫抑制的主要目标。

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摘要

Plaque-forming cell responses against sheep erythrocytes, Escherichia coli lipopolysaccharide, pneumococcal polysaccharide, and polyvinylpyrrolidone were examined in mice infected with lymphocytic choriomeningitis virus. A 92 to 96 percent reduction of the thymus-dependent anti-sheep erythrocyte responses was observed 2 to 4 weeks after infection. However, the thymus-independent responses against the three other antigens were close to normal at all stages of the infetion. Studies on allograft immunity of infected C3H mice against DBA/2 mastocytoma cells revealed a severe suppression of the T cell-mediated cytotoxic response which was temporally related to the impaired humoral responsiveness against sheep erythrocytes. The capacity of spleen cells from infected mice to restore immune responsiveness of lethally irradiated recipients against sheep erythrocytes was significantly reduced. The adoptive responses, however, were clearly improved when normal thymus cells were added to the inferior spleen cells. Moreover, it appeared that the spleen cells from immunosuppressed donor mice could not confer suppression to normal lymphoid cells. The presented findings are consistent with the assumption that a numeric deficiency of T cells, or cells belonging to some T cell subpopulation, is the primary cause of lymphocytic choriomeningitis virus-induced immunosuppression.
机译：在感染淋巴细胞脉络膜训练炎病毒感染的小鼠中，检查了对绵羊红细胞，大肠杆菌脂多糖，肺炎球菌多糖和聚乙烯吡咯烷酮的斑块形成细胞反应。感染后2至4周观察到胸腺依赖性抗羊红细胞反应的92％至96％。然而，对另外三种抗原的胸腺无关的反应在无感染的所有阶段接近正常。对DBA / 2乳细胞瘤细胞感染C3H小鼠同种异体移植免疫的研究显示，严重抑制T细胞介导的细胞毒性反应，其与绵羊红细胞的体液反应性受损时在时间上存在。来自受感染的小鼠的脾细胞恢复致命辐照的接受者对绵羊红细胞的免疫反应性的能力显着降低。然而，当将正常的胸腺细胞加入到下脾细胞中，清楚地改善了过的反应。此外，似乎来自免疫抑制供体小鼠的脾细胞不能赋予正常淋巴细胞的抑制。呈现的研究结果与假设T细胞的数值缺陷或属于某些T细胞亚群的细胞是淋巴细胞核化炎病毒诱导的免疫抑制的主要原因。

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