Analysis of Minimal Functions of Simian Virus 40 III. Evidence for “Host Cell Repair” of Oncogenicity and Infectivity of UV-Irradiated Simian Virus 40

N. H. Seemayer; V. Defendi

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Analysis of Minimal Functions of Simian Virus 40 III. Evidence for “Host Cell Repair” of Oncogenicity and Infectivity of UV-Irradiated Simian Virus 40

机译：猿猴病毒40 III的最小功能分析。紫外线辐照硅藻病毒40的致癌性和感染性“宿主细胞修复”的证据

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The in vitro transforming capacity of simian virus 40 (SV40) for Syrian hamster cells is highly resistant to inactivation by UV light in comparison to infectivity. In the same cell system, we demonstrated a “host cell repair mechanism” sensitive to caffeine which is, to a large extent, responsible for the high resistance to UV inactivation of the transforming capacity of SV40. The survival of infectivity of UV-irradiated SV40 in CV-1 cells was also sensitive to caffeine, again indicating host cell repair. On the other hand, depression of normal cell DNA synthesis by hydroxyurea during the first 24 h postinfection only modestly reduced, and to a similar extent, the transforming capacity of UV-irradiated and nonirradiated SV40.

机译：与感染性相比，叙利亚仓鼠细胞的Simian病毒40（SV40）的体外转化能力对UV光的抗动性具有高度抗性。在相同的细胞系统中，我们证明了对咖啡因敏感的“宿主细胞修复机制”，其在很大程度上，负责高抗紫外线灭活SV40的变换能力。 CV-1细胞中紫外线辐照的SV40的感染性的存活对咖啡因也敏感，同样表明宿主细胞修复。另一方面，在前24小时期间，羟基脲的正常细胞DNA的抑制仅在前24小时染色，并且在相似的程度上，紫外线辐照和非辐照的SV40的变换能力。

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《Journal of Virology》 |1974年第1期|共6页
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N. H. Seemayer; V. Defendi;
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收录信息美国《科学引文索引》(SCI);
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1. Analysis of Minimal Functions of Simian Virus 40 III. Evidence for “Host Cell Repair” of Oncogenicity and Infectivity of UV-Irradiated Simian Virus 40 [J] . N. H. Seemayer, V. Defendi Journal of Virology . 1974,第1期

机译：猿猴病毒40 III的最小功能分析。紫外线辐照硅藻病毒40的致癌性和感染性“宿主细胞修复”的证据
2. Analysis of Minimal Functions of Simian Virus 40 III. Evidence for “Host Cell Repair” of Oncogenicity and Infectivity of UV-Irradiated Simian Virus 40 [J] . N. H. Seemayer, V. Defendi Journal of Virology . 1974,第1期

机译：猿猴病毒40 III的最小功能分析。紫外线辐照硅藻病毒40的致癌性和感染性“宿主细胞修复”的证据
3. Control of Simian Virus 40 Gene Expression in Adenovirus-Simian Virus 40 Hybrid Viruses Synthesis of Hybrid Adenovirus 2-Simian Virus 40 RNA Molecules in Cells Infected with a Nondefective Adenovirus 2-Simian Virus 40 Hybrid Virus [J] . Michael N. Oxman, Myron J. Levin, Andrew M. Lewis Journal of Virology . 1974,第2期

机译：Simian病毒40基因表达在腺病毒-imian病毒40杂交病毒中的合成杂交腺病毒2-猿猴病毒40 RNA分子用NondeFective腺病毒2-猿猴病毒40杂交病毒感染
4. Computational Analysis of Nucleosome Positioning Signals in the Simian Virus 40 Chromatin [C] . Hongyan Zhao, Hong Yan International MultiConference of Engineers and Computer Scientists . 2009

机译：亚麻病毒40染色质中核心定位信号的计算分析
5. CHARACTERIZATION OF THE NUCLEAR MATRIX PREPARED FROM CELLS INFECTED WITH SIMIAN VIRUS 40 (REPLICATION). [D] . JONES, CLINTON JIMMIE. 1985

机译：从感染猿猴病毒40的细胞中制备的核基质的特性（复制）。
6. Analysis of Minimal Functions of Simian Virus 40 III. Evidence for Host Cell Repair of Oncogenicity and Infectivity of UV-Irradiated Simian Virus 40 [O] . N. H. Seemayer, V. Defendi 1974

机译：猿猴病毒40的最小功能分析。紫外线辐照猿猴病毒的致癌性和感染性的宿主细胞修复证据40
7. Analysis of Minimal Functions of Simian Virus 40 III. Evidence for “Host Cell Repair” of Oncogenicity and Infectivity of UV-Irradiated Simian Virus 40 [O] . N. H. Seemayer, V. Defendi 1974

机译：猿猴病毒40 III的最小功能分析。紫外线辐照硅藻病毒40的致癌性和感染性“宿主细胞修复”的证据

Analysis of Minimal Functions of Simian Virus 40 III. Evidence for “Host Cell Repair” of Oncogenicity and Infectivity of UV-Irradiated Simian Virus 40

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