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首页> 外文期刊>Journal of Virology >Buoyant Density of the Hepatitis A Virus-Like Particle in Cesium Chloride
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Buoyant Density of the Hepatitis A Virus-Like Particle in Cesium Chloride

机译：丙型肝炎的肝炎浮能密度在氯化铯中的病毒样颗粒

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We recently visualized by immune electron microscopy a virus-like particle in the stools of patients with hepatitis A. The particle measured approximately 27 nm in diameter and morphologically resembled a picornavirus or parvovirus. To further characterize this particle, we have determined its buoyant density in cesium chloride (CsCl) by ultracentrifugation. Hepatitis A particles from three positive stool specimens were isopycnically banded in separate experiments, and the gradient fractions were examined for particles by immune electron microscopy by using hepatitis A convalescent sera. In each experiment, the particles were observed in a normal distribution about a peak fraction with a mean density of approximately 1.4 g/cm3. The buoyant density of 1.4 g/cm3 in CsCl together with its morphology and the reported resistance of hepatitis virus to acid, ether, and heat suggest that this particle is parvovirus-like.
机译：我们最近通过免疫电子显微镜可视化了甲型肝炎患者粪便中的病毒样颗粒。颗粒直径测量约27nm，形态学地类似于皮革病毒或剖腹症。为了进一步表征该颗粒，我们通过超速离心确定了氯化铯（CSCl）中的浮力密度。甲型肝炎在单独的实验中，来自三个正粪便标本的颗粒在单独的实验中被同样地带，并且通过使用甲型肝炎血清，通过免疫电子显微镜检查梯度级分。在每个实验中，在正常分布的正常分布中观察颗粒，峰值级分，平均密度为约1.4g / cm 3 。 CSCL中的浮力密度为1.4g / cm 3 的形态和肝炎病毒对酸，乙醚和热量的报告抗性表明该颗粒是剖腹症状的。

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