Detection of Naturally Occurring Antibodies to RNA-Dependent DNA Polymerase of Murine Leukemia Virus in Kidney Eluates of AKR Mice

V. W. Hollis; T. Aoki; O. Barrera; M. B. A. Oldstone; F. J. Dixon

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Detection of Naturally Occurring Antibodies to RNA-Dependent DNA Polymerase of Murine Leukemia Virus in Kidney Eluates of AKR Mice

机译：检测AKR小鼠肾脏蛋氨酸中鼠白血病病毒RNA依赖性DNA聚合酶的天然存在的抗体

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Specific antibodies to the RNA-dependent DNA polymerase (reverse transcriptase) of murine type C viruses have been isolated from the renal glomeruli of both leukemic and nonleukemic AKR mice where they presumably had been deposited as immune complexes. The antibodies were shown to have sedimentation coefficients of 26S to 28S and 5S to 7S on sucrose rate zonal centrifugation. Inactivation with monospecific antisera to various mouse immunoglobulins identified antibodies as being in both immunoglobulin (IGM) and IgG classes. In addition, these antibodies only reacted with the reverse transcriptase from murine and feline type C viruses, but not the polymerase from avian myeloblastosis virus (AMV). Our results provide additional evidence for the lack of immunological tolerance and demonstrate the presence of another immune complex system in AKR kidneys.

机译：对鼠型C病毒的RNA依赖性DNA聚合酶（逆转录酶）的特异性抗体已从白血病和非血症Akr小鼠的肾性肾小球中分离，其中它们可能已经沉积为免疫复合物。显示抗体在蔗糖上具有26℃的沉降系数26 S 和5 S 至7 S 率区分离心。用单特异性抗血清灭活各种小鼠免疫球蛋白鉴定在免疫球蛋白（IgM）和IgG等级中的抗体。此外，这些抗体仅与来自鼠和猫型C病毒的逆转录酶反应，但不是来自禽骨脲母细胞病毒（AMV）的聚合酶。我们的结果为缺乏免疫耐受性提供了额外的证据，并证明了AKR肾脏中另一种免疫复合体系的存在。 展开▼

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《Journal of Virology》 |1974年第2期|共7页

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V. W. Hollis; T. Aoki; O. Barrera; M. B. A. Oldstone; F. J. Dixon;
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收录信息美国《科学引文索引》(SCI);

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1. Detection of Naturally Occurring Antibodies to RNA-Dependent DNA Polymerase of Murine Leukemia Virus in Kidney Eluates of AKR Mice [J] . V. W. Hollis, T. Aoki, O. Barrera, Journal of Virology . 1974,第2期

机译：检测AKR小鼠肾脏蛋氨酸中鼠白血病病毒RNA依赖性DNA聚合酶的天然存在的抗体

2. Detection of Naturally Occurring Antibodies to RNA-Dependent DNA Polymerase of Murine Leukemia Virus in Kidney Eluates of AKR Mice [J] . V. W. Hollis, T. Aoki, O. Barrera, Journal of Virology . 1974,第2期

机译：检测AKR小鼠肾脏蛋氨酸中鼠白血病病毒RNA依赖性DNA聚合酶的天然存在的抗体

3. QUANTITATIVE STUDIES OF NATURALLY OCCURRING MURINE LEUKEMIA VIRUS INFECTION OF AKR MICE [J] . Wallace P. Rowe, Theodore Pincus The Journal of Experomental Medicine . 1972,第2期

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4. A Real-time Quantitative PCR-based Method for the Detection and Quantification of Xenotropic Murine Leukemia Virus (X-MuLV) and its Application in Evaluation of X-MuLV Removal during Pharmaceutical Protein Purification [C] . Liming Shi, Qi Chen, Lenore A. Norling, 2002 International Symposium on Safety Science and Technology (2002 ISSST) Vol.3 Pt.A Oct 10-13, 2002 Tai'an, China . 2002

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Detection of Naturally Occurring Antibodies to RNA-Dependent DNA Polymerase of Murine Leukemia Virus in Kidney Eluates of AKR Mice

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