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Host Cell Regulation of Induction of Epstein-Barr Virus

机译:Epstein-Barr病毒诱导的宿主细胞调节

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When Epstein-Barr virus (EBV) negative cells (Raji) were treated with iododeoxyuridine, only the early antigen (EA) component was induced. There was no significant increase in EBV DNA and no virus particles were observed. Somatic-cell hybrids were prepared from the fusion of Raji and D98 cells (D98/Raji). When these cells were treated with iododeoxyuridine, early antigen EBV DNA, and virus particles were synthesized. These data suggest cellular control over the expression of the EBV genome.
机译:当用碘氧基尿苷处理Epstein-Barr病毒(EBV)阴性细胞(Raji)时,诱导早期抗原(EA)组分。 EBV DNA没有显着增加,没有观察到病毒颗粒。由Raji和D98细胞的融合制备体细胞细胞杂种(D98 / Raji)。当用碘氧基尿苷处理这些细胞,合成早期抗原EBV DNA和病毒颗粒。这些数据表明细胞控制对EBV基因组的表达。

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