DNA sequence of the Bryan high-titer strain of Rous sarcoma virus: extent of env deletion and possible genealogical relationship with other viral strains.

T L Lerner; H Hanafusa

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DNA sequence of the Bryan high-titer strain of Rous sarcoma virus: extent of env deletion and possible genealogical relationship with other viral strains.

机译：BRYAN高滴度菌株的DNA序列肉瘤病毒：ENV删除程度和与其他病毒菌株可能的族族关系。

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The genetic structure of the Bryan high-titer strain of Rous sarcoma virus (BH-RSV) was analyzed by using a molecular clone obtained from proviral DNA. DNA sequencing of the pol-src junction of BH-RSV revealed that the env sequence was almost entirely absent; only six base pairs following the pol termination codon remained. Beginning at nucleotide 7 (relative to the end of pol), a 91-base pair sequence identical to the 91 base pairs immediately upstream from src in other strains of RSV was found. The helper virus-related sequence of about 100 base pairs, which is present as a direct repeat in the 5' and 3' regions flanking src in other RSVs, was present only on the 3' side of src in BH-RSV. The 3' end of BH-RSV, from the last 16 base pairs of src through the U3 region, was virtually identical to a region downstream of env through U3 in the nontransforming helper virus Rous-associated virus-2, suggesting that BH-RSV may have been derived by recombination between Rous-associated virus-2 and cellular src DNA. The possibility that the original RSV may have been a defective transforming virus and a precursor of the nondefective RSV strains is discussed.

机译：通过使用从ProViral DNA获得的分子克隆分析了BRYAN高滴度菌株的BRYAN高滴度菌株（BH-RSV）的遗传结构。 BH-RSV的POL-SRC结的DNA测序显示ENV序列几乎完全没有; POL终止密码子只有六对留下。在核苷酸7（相对于Pol的末端）开始，发现与在其他RSV的其他菌株中的SRC上游的91碱基对序列相同。辅助病毒相关序列约为100个碱基对存在于其他RSV中的SRC中的5'和3'区中的直接重复，仅在BH-RSV中的SRC的3'侧存在。 BH-RSV的3'末端通过U3区域的最后16个基对，几乎与env通过U3下游的区域相同，在非格式格式辅助病毒不相关的病毒-2中，表明BH-RSV可能是通过在相关的病毒-2和细胞Src DNA之间的重组来源的。原始RSV可能是有缺陷的转化病毒的可能性和裸射RSV菌株的前体。

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《Journal of Virology》 |1984年第2期|共8页
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T L Lerner; H Hanafusa;
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收录信息美国《科学引文索引》(SCI);
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1. DNA sequence of the Bryan high-titer strain of Rous sarcoma virus: extent of env deletion and possible genealogical relationship with other viral strains. [J] . T L Lerner, H Hanafusa Journal of Virology . 1984,第2期

机译：BRYAN高滴度菌株的DNA序列肉瘤病毒：ENV删除程度和与其他病毒菌株可能的族族关系。
2. DNA sequence of the Bryan high-titer strain of Rous sarcoma virus: extent of env deletion and possible genealogical relationship with other viral strains. [J] . T L Lerner, H Hanafusa Journal of Virology . 1984,第2期

机译：BRYAN高滴度菌株的DNA序列肉瘤病毒：ENV删除程度和与其他病毒菌株可能的族族关系。
3. Viral glycoprotein synthesis studies in an established line of Japanese quail embryo cells infected with the Bryan high-titer strain of Rous sarcoma virus. [J] . M S Halpern, D P Bolognesi, R R Friis Journal of Virology . 1976,第2期

机译：病毒糖蛋白合成研究中的日本鹌鹑胚细胞的成熟系列感染了Bryan高滴度菌株的Rous Sarcoma病毒。
4. Characterization of DNA-protein interactions involved in Marek's disease virus-mediated rous sarcoma virus long terminal repeat promoter transactivation [D] . Sun, Wei. 1997

机译：涉及马立克氏病病毒介导的肉瘤肉瘤长末端重复启动子反式激活的DNA-蛋白质相互作用的表征
5. DNA sequence of the Bryan high-titer strain of Rous sarcoma virus: extent of env deletion and possible genealogical relationship with other viral strains. [O] . T L Lerner, H Hanafusa 1984

机译：劳斯肉瘤病毒Bryan高滴度病毒株的DNA序列：env缺失的程度以及与其他病毒株的可能谱系关系。
6. Polymerase-defective mutant of the Bryan high-titer strain of Rous sarcoma virus. [O] . Sudol, M, Lerner, T L, Hanafusa, H 1986

机译：劳斯肉瘤病毒Bryan高滴度病毒株的聚合酶缺陷型突变体。

DNA sequence of the Bryan high-titer strain of Rous sarcoma virus: extent of env deletion and possible genealogical relationship with other viral strains.

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