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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Long-Term Protective Immunity of Recipients of the OKA Strain of Live Varicella Vaccine
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Long-Term Protective Immunity of Recipients of the OKA Strain of Live Varicella Vaccine

机译：活性水痘疫苗的Oka菌株的长期保护免疫

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In spite of close contacts with patients who had varicella, 101 of 106 (95%) healthy and sick children (142 of 147 (97%) exposures of these children) who had received the OKA strain of live varicella vaccine 7 to 10 years earlier were protected against the disease completely. Among them, 37 of 38 (97%) vaccine recipients who received immunologic testing had varicella-zoster virus (VZV) antibodies tested by fluorescent antibody to membrane antigen method with a geometric mean titer of 1:9.3, and 37 of the 38 (97%) showed positive skin reaction to varicella-zoster virus antigen with erythema (mean diameter 13.4 mm). These findings were compared with those for 29 children who had contracted typical varicella 7 to 10 years earlier, whose seropositive rate was 100% with a geometric mean titer of 1:10.5, and 97% of whom (28/29) had positive skin reaction with mean diameter of 12.9 mm. These results indicate that the vaccine-induced protective immunity persists for approximately one decade and is almost equal to the long-term immunity following natural infection.
机译：尽管有与患者的患者接触，但是106名（95％）的健康和病人的病毒儿童（这些儿童的147名（97％（97％（97％）的患者），他们已经收到了7至10年的Live VariCella疫苗的Oka菌株完全保护疾病。其中38个（97％）疫苗接受者接受免疫检测的疫苗接受者具有由荧光抗体测试的Varicella-Zoster病毒（VZV）抗体，其几何平均滴度为1：9.3和38的37（97个％）向种子果实 - 带状疱疹病毒抗原的阳性皮肤反应显示出红斑（平均直径13.4mm）。将这些发现与29名儿童进行了比较，其中典型的水痘7至10年，其血清率为100％，几何平均滴度为1：10.5，其中97％（28/29）具有阳性皮肤反应平均直径为12.9毫米。这些结果表明，疫苗诱导的保护性免疫持续大约十年，几乎等于自然感染后的长期免疫力。

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