Gene expression of ornithine decarboxylase in L1210 leukaemia cells exposed to dl-2-difluoromethylornithine in the presence of cadaverine

J J?nne; L Alhonen-Hongisto; O A J?nne; R Sinervirta

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Gene expression of ornithine decarboxylase in L1210 leukaemia cells exposed to dl-2-difluoromethylornithine in the presence of cadaverine

机译：L1210白血病细胞中的鸟氨酸脱羧酶的基因表达暴露于D1-2-二氟甲基胺的尸胺

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pCultured mouse L1210 leukaemia cells treated with DL-2-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase (EC 4.1.1.17), in the presence of micromolar concentrations of cadaverine, started to overproduce ornithine decarboxylase after an exposure of several weeks. The more than 60-fold excess of the enzyme protein in the drug-treated cells apparently resulted from a strikingly enhanced accumulation of mRNA for the enzyme associated with only a modest (about 2-fold) gene amplification./p

机译：>培养的小鼠L1210用DL-2-二氟甲基胺处理的白血病细胞，在尸体摩尔浓度的尸体浓度存在下，在尸体浓度的情况下，在幼野浓度的存在下，在接触几周后开始过量氧胆碱脱羧酶。药物处理细胞中超过60倍过量的酶蛋白显然是由于与仅适度（约2倍）基因扩增相关的酶的mRNA的显着增强。

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《The biochemical journal》 |1985年第2期|共页
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J J?nne; L Alhonen-Hongisto; O A J?nne; R Sinervirta;
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1. Gene expression of ornithine decarboxylase in L1210 leukaemia cells exposed to dl-2-difluoromethylornithine in the presence of cadaverine [J] . J J?nne, L Alhonen-Hongisto, O A J?nne, The biochemical journal . 1985,第2期

机译：L1210白血病细胞中的鸟氨酸脱羧酶的基因表达暴露于D1-2-二氟甲基胺的尸胺
2. Gene expression of ornithine decarboxylase in L1210 leukaemia cells exposed to dl-2-difluoromethylornithine in the presence of cadaverine [J] . J J?nne, L Alhonen-Hongisto, O A J?nne, The biochemical journal . 1985,第2期

机译：L1210白血病细胞中的鸟氨酸脱羧酶的基因表达暴露于D1-2-二氟甲基胺的尸胺
3. Cadaverine supplementation during a chronic exposure to difluoromethylornithine allows an overexpression, but prevents gene amplification, of ornithine decarboxylase in L1210 mouse leukaemia cells [J] . A Hirvonen, J J?nne, L Alhonen-Hongisto, The biochemical journal . 1987,第3期

机译：在长期暴露于二氟甲基鸟氨酸的过程中补充卡达维林可使L1210小鼠白血病细胞中鸟氨酸脱羧酶过表达，但阻止基因扩增
4. Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistantmouse leukemia L1210 cells that lack p53 expression: convergence at caspase-3 activation [C] . Ann H. Cory, Caroline C. Edwards, Jennifer G. Hall, International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：不同代谢步骤的抑制剂导致缺乏p53表达的脱氧腺苷抵抗疗效中的细胞凋亡增加：Caspase-3活化的收敛性
5. THE REGULATION OF ORNITHINE DECARBOXYLASE ACTIVITY IN CONTINUOUSLY DIVIDING CELLS AND QUIESCENT CELLS STIMULATED TO PROLIFERATE. [D] . CRESS, ANNE ELIZABETH. 1980

机译：连续分裂的细胞和经刺激增殖的静止型细胞中鸟氨酸脱羧酶活性的调节。
6. Gene expression of ornithine decarboxylase in L1210 leukaemia cells exposed to DL-2-difluoromethylornithine in the presence of cadaverine. [O] . L Alhonen-Hongisto, R Sinervirta, O A Jänne, 1985

机译：在尸胺存在下暴露于DL-2-二氟甲基鸟氨酸的L1210白血病细胞中鸟氨酸脱羧酶的基因表达。
7. Gene expression of ornithine decarboxylase in L1210 leukaemia cells exposed to DL-2-difluoromethylornithine in the presence of cadaverine. [O] . Alhonen-Hongisto, L, Sinervirta, R, Jänne, O A, 1985

机译：在尸胺存在下暴露于DL-2-二氟甲基鸟氨酸的L1210白血病细胞中鸟氨酸脱羧酶的基因表达。
8. Ornithine Decarboxylase Inhibition and the Malaria-Infected Red Cell: A Model for Polyamine Metabolism and Growth [R] . Whaun, J. M., Brown, N. D. 1985

机译：鸟氨酸脱羧酶抑制和疟疾感染的红细胞：多胺代谢和生长的模型

Gene expression of ornithine decarboxylase in L1210 leukaemia cells exposed to dl-2-difluoromethylornithine in the presence of cadaverine

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